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Comment
. 2018 Apr 17;115(16):E3604-E3605.
doi: 10.1073/pnas.1803533115. Epub 2018 Mar 27.

Reply to Gilchrist et al.: Possible roles for VAC14 in multiple infectious diseases

Monica I Alvarez  1 , Dennis C Ko  2   3
Affiliations
Comment

Reply to Gilchrist et al.: Possible roles for VAC14 in multiple infectious diseases

Monica I Alvarez et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Geographic distribution of SNP rs8060947.The G allele is ancestral and protective against certain bacterial pathogens; the A allele is derived and associated with susceptibility. Map generated from the Geography of Genetic Variants Browser (11).
See this image and copyright information in PMC

Comment on

References

    1. Alvarez MI, et al. Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol. Proc Natl Acad Sci USA. 2017;114:E7746–E7755. - PMC - PubMed
    1. Gilchrist JJ, et al. Wellcome Trust Case Control Consortium 2; Kenyan Bacteraemia Study Group Genetic variation in VAC14 is associated with bacteremia secondary to diverse pathogens in African children. Proc Natl Acad Sci USA. 2018;115:E3601–E3603. - PMC - PubMed
    1. Santos AJ, Meinecke M, Fessler MB, Holden DW, Boucrot E. Preferential invasion of mitotic cells by Salmonella reveals that cell surface cholesterol is maximal during metaphase. J Cell Sci. 2013;126:2990–2996. - PMC - PubMed
    1. Zhou M, et al. Membrane cholesterol plays an important role in enteropathogen adhesion and the activation of innate immunity via flagellin-TLR5 signaling. Arch Microbiol. 2015;197:797–803. - PubMed
    1. Jin JS, et al. Acinetobacter baumannii secretes cytotoxic outer membrane protein A via outer membrane vesicles. PLoS One. 2011;6:e17027. - PMC - PubMed

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