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. 2018 Apr 20;83(8):4598-4605.
doi: 10.1021/acs.joc.8b00341. Epub 2018 Apr 6.

Cu-Mediated Sulfonyl Radical-Enabled 5- exo-trig Cyclization of Alkenyl Aldehydes: Access to Sulfonylmethyl 1 H-Indenes

Jiabin Ni  1   2   3 , Yu Xue  1   2   4 , Liping Sun  4 , Ao Zhang  1   2   3
Affiliations

Cu-Mediated Sulfonyl Radical-Enabled 5- exo-trig Cyclization of Alkenyl Aldehydes: Access to Sulfonylmethyl 1 H-Indenes

Jiabin Ni et al. J Org Chem. .

Abstract

An efficient method for the construction of sulfonylmethyl 1 H-indenes via Cu(I)-mediated sulfonyl radical-enabled 5- exo-trig cyclization of alkenyl aldehydes has been developed for the first time. Mechanistic studies indicated that a radical addition-cyclization-elimination (RACE) process might be involved. The reaction features a relatively broad substrate scope, good annulation efficiency, and varying functional group tolerance.

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