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Comment
. 2018 Mar 27;114(6):1255-1256.
doi: 10.1016/j.bpj.2018.01.037.

Bigger Isn't Always Better: Bulking Up Impedes Receptor Internalization

Anne K Kenworthy  1
Affiliations
Comment

Bigger Isn't Always Better: Bulking Up Impedes Receptor Internalization

Anne K Kenworthy. Biophys J. .
No abstract available

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Figures

Figure 1
Figure 1
Bulky ligands cause receptors to be sterically excluded from clathrin-coated structures. (Top) At low expression levels, receptor-ligand complexes have an equal probability of entering into clathrin-coated structures regardless of the size of the complex. (Bottom) When the density of receptors in the plasma membrane is high, larger receptor-ligand complexes become sterically saturated as the result of the entropic costs of confining them. (Inset) Structure of the engineered receptor-ligand complexes. GFP, green fluorescent protein; GFPnb, GFP nanobody; RFP, red fluorescent protein.
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