Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Mar 27;17(1):57.
doi: 10.1186/s12944-018-0688-6.

Exploring the potential of black tea based flavonoids against hyperlipidemia related disorders

Ali Imran  1 , Masood Sadiq Butt  2 , Muhammad Sajid Arshad  3 , Muhammad Umair Arshad  1 , Farhan Saeed  1 , Muhammad Sohaib  4 , Rizwan Munir  5
Affiliations

Exploring the potential of black tea based flavonoids against hyperlipidemia related disorders

Ali Imran et al. Lipids Health Dis. .

Abstract

Background: In recent decade, Hyperlipidemia related disorders like obesity, hypercholesterolemia and diabetes are considered as the leading killers for mankind. Fundamental nexus between nutrition and health diverting the consumers focus towards plant based natural products as a remedy against various metabolic syndrome. Considering this, present study was conducted to explicate the role of black tea polyphenols such as Theaflavins and thearubigins therapeutic potential to tackle targeted maladies especially oxidative stress related disorders like hypercholesterolemia and diabetes.

Methods: The mandate of current investigation was to explore the hypoglycemic and hypocholestrolemic perspective of isolated theaflavin and thearubigins through a model feeding trial. For the purpose, theaflavin & thearubigins were isolated from black tea through solvent partition method and utilize to form three types of nutraceutical drinks (theaflavin, thearubigins & theaflavin + thearubigins based) alongside control to be further utilized in bioefficacy trial. In bioefficacy trial, three types of independent studies were design on the bases of diet by involving 20 male wistar rats in each study (5 for each group). In study I, normal diet was administrated while, in study II & III high cholesterol and high sucrose diet was given, respectively along with prepared nutraceutical drinks to synchronize their therapeutic effect for a period of 56 days. At the termination of trial, Feed & drink intakes, body weight, total cholesterol, LDL, HDL, triglycerides, glucose and insulin levels were measured.

Results: The results indicated reduction in cholesterol, LDL and triglycerides levels of experimental rats in all studies with significant increase in HDL. In this context, theaflavin based drink imparted maximum reduction in cholesterol (3.75, 11.03 & 10.39%), LDL (3.84, 14.25& 10.84%) & triglycerides (2.99, 8.54 & 6.65%) in respective studies compared to thearubigins and theaflavin + thearubigins based drinks. However, theaflavin+ thearubigins based drink caused highest glucose decline and maximum insulin increase in all studies as compared to other nutraceutical drinks. The reported value for the insulin increase were 13.02 ± 1.02 & 14.55 ± 1.13, 10.09 ± 0.15 & 11.59 ± 0.86 for Hyperglycemic and Hypocholestrolemic rats respectively compared to control (7.84 ± 0.45 & 9.10 ± 0.41) for study I and II.

Conclusions: In the nutshell, theaflavin and thearubigins based dietary interventions are helpful to alleviate the hypercholestrolemia and hyperglycemia and should be promoted as parallel therapy to combat these disorders.

Keywords: Dietary interventions; Flavonoids; Hyperlipidemia; Thearubigins.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Absolute values for Extraction yield for isolated theaflavins and thearubigins from Black tea (QI-Men)
Fig. 2
Fig. 2
Agglomerative hierarchical clustering (AHC) of different studied attributes (dendogram)
Fig. 3
Fig. 3
PCA analysis of the studied attributes showing the % share of two main factors (F1 and F2) in total variability
Fig. 4
Fig. 4
Diet plan used in all studies
Fig. 5
Fig. 5
Drink plan used in all studies
Fig. 6
Fig. 6
Average body weight at the termination of all studies
Fig. 7
Fig. 7
Percent reduction in cholesterol in all studies (both trials) by administration of theaflavin, thearubigins and combination of theaflavin & thearubigins based drink in rats
Fig. 8
Fig. 8
Percent increase in HDL in all studies (both trials) by administration of theaflavin, thearubigins and combination of theaflavin & thearubigins based drink in rats
Fig. 9
Fig. 9
Percent decrease in LDL in all studies (both trials) caused by theaflavin, thearubigins and combination of theaflavin & thearubigins based drink in rats
Fig. 10
Fig. 10
Percent diminish in triglycrides levels in all studies (both trials) caused by theaflavin, thearubigins and combination of theaflavin & thearubigins based drink in rats
Fig. 11
Fig. 11
Percent reduction in glucose as compared to control in all studies
Fig. 12
Fig. 12
Percent increase in insulin as compared to control in all studies
See this image and copyright information in PMC

References

    1. World Health Organization . Prevalence of diabetes in the WHO eastern Mediterranean region. 2006.
    1. Schlesier K, Kühn B, Kiehntop M, Winnefeld K, Roskos M, Bitsch R, Böhm V. Comparative evaluation of green and black tea consumption on the iron status of omnivorous and vegetarian people. Food Res Int. 2012;46:522–527. doi: 10.1016/j.foodres.2011.06.019. - DOI
    1. Imran A, Butt MS, Sharif MK. Phytochemical density of some promising commercial tea brands. Int J Food Prop. 2012;15(1):99–108. doi: 10.1080/10942911003754650. - DOI
    1. Alipoor B, Rad AH. A review on the therapeutical effects of tea. Asian J Clin Nutri. 2012;4(1):1–15. doi: 10.3923/ajcn.2012.1.15. - DOI
    1. Yang CS, Wang X, Lu G, Picinich SC. Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Can. 2009;9(6):429–439. doi: 10.1038/nrc2641. - DOI - PMC - PubMed

LinkOut - more resources