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Review
. 2018 Mar 28;10(434):eaan2595.
doi: 10.1126/scitranslmed.aan2595.

Medication development in opioid addiction: Meaningful clinical end points

Nora D Volkow  1 , Janet Woodcock  2 , Wilson M Compton  3 , Douglas C Throckmorton  2 , Phil Skolnick  3 , Sharon Hertz  2 , Eric M Wargo  3
Affiliations
Review

Medication development in opioid addiction: Meaningful clinical end points

Nora D Volkow et al. Sci Transl Med. .

Abstract

The FDA's "abstinence" outcome measure for approval of new medications to treat opioid-use disorders has been difficult to achieve; developing and validating alternative meaningful outcomes could facilitate drug development.

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