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. 2018 Mar 15;13(T-NANO 2014 Abstracts):79-82.
doi: 10.2147/IJN.S124708. eCollection 2018.

Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle

Krupa Kansara  1 , Pal Patel  1 , Ritesh K Shukla  1 , Alok Pandya  1 , Rishi Shanker  1 , Ashutosh Kumar  1 , Alok Dhawan  1
Affiliations

Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle

Krupa Kansara et al. Int J Nanomedicine. .

Erratum in

Abstract

Over the last decade, there has been growing interest in developing novel nanoparticles (NPs) for biomedical applications. A safe-by-design approach was used in this study to synthesize biocompatible iron oxide NPs. The size of the particles obtained was ~100 nm. Although these NPs were significantly (P<0.05) internalized in MCF-7 (human breast adenocarcinoma cell line) cells, no adverse effect was observed in the cells as assessed by cytotoxicity assays (neutral red uptake and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) and cell cycle analysis. Our data demonstrate the potential of iron oxide NPs as a biocompatible carrier for targeted drug delivery.

Keywords: biocompatible iron oxide nanoparticles; coprecipitation; human breast adenocarcinoma cells.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Internalization of Fe3O4 NPs in MCF-7 cells using flow cytometry. Notes: Data are expressed as mean ± standard error of the mean from three independent experiments. *P<0.05, when compared with control. Abbreviations: NPs, nanoparticles; MCF-7, human breast adenocarcinoma cell line.
Figure 2
Figure 2
Cytotoxicity of Fe3O4 NPs in MCF-7 cells. (A) NR uptake (%); (B) MTT reduction (%). Notes: The viability of the control cells was considered as 100%. Data are expressed as mean ± standard error of the mean from three independent experiments. Abbreviations: NPs, nanoparticles; MCF-7, human breast adenocarcinoma cell line; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NR, neutral red.
Figure 3
Figure 3
Effect of Fe3O4 NPs on cell cycle progression in MCF-7 cells (A) control (B–E) cells treated with different concentration of Fe3O4 NPs and (F) cells treated with 4 mM EMS. Abbreviations: EMS, ethylmethane sulfonate; NPs, nanoparticles; MCF-7, human breast adenocarcinoma cell line.
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