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Review
. 2018 Mar 12:9:138.
doi: 10.3389/fneur.2018.00138. eCollection 2018.

Structural and Functional Brain Patterns of Non-Motor Syndromes in Parkinson's Disease

Tino Prell  1
Affiliations
Review

Structural and Functional Brain Patterns of Non-Motor Syndromes in Parkinson's Disease

Tino Prell. Front Neurol. .

Abstract

Parkinson's disease (PD) is a common, progressive and multisystem neurodegenerative disorder characterized by motor and non-motor symptoms. Advanced magnetic resonance imaging, positron emission tomography, and functional magnetic resonance imaging can render the view toward understanding the neural basis of these non-motor syndromes, as they help to understand the underlying pathophysiological abnormalities. This review provides an up-to-date description of structural and functional brain alterations in patients with PD with cognitive deficits, visual hallucinations, fatigue, impulsive behavior disorders, sleep disorders, and pain.

Keywords: Parkinson’s disease; cognition; fatigue; imaging; impulsive behavior disorders; pain; positron emission tomography.

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Figures

Figure 1
Figure 1
Overview of resting-state networks. The figure shows the consistent reported resting-state networks: the default mode network, the sensorimotor, the insular/temporal and anterior cingulate cortex regions, the salience, the executive control, and the visual network (figures developed with SPM 8, www.fil.ion.ucl.ac.uk/spm).
Figure 2
Figure 2
Overview of resting-state networks mainly involved in non-motor syndromes in Parkinson’s disease (PD).
See this image and copyright information in PMC

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