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Review
. 2018 Feb;7(1):145-154.
doi: 10.21037/tau.2017.12.33.

On cribriform prostate cancer

Charlotte F Kweldam  1 , Theodorus van der Kwast  2 , Geert J van Leenders  1
Affiliations
Review

On cribriform prostate cancer

Charlotte F Kweldam et al. Transl Androl Urol. 2018 Feb.

Abstract

The management of newly diagnosed prostate cancer is challenging because of its heterogeneity in histology, genetics and clinical outcome. The clinical outcome of patients with Gleason score 7 prostate cancer varies greatly. Improving risk assessment in this group is of particular interest, as Gleason score 7 prostate cancer on biopsy is an important clinical threshold for active treatment. Architecturally, four Gleason grade 4 growth patterns are recognized: ill-formed, fused, glomeruloid and cribriform. The aim of this review is to describe the role of cribriform growth in prostate cancer with respect to diagnosis, prognosis and molecular pathology. Secondly, we will discuss clinical applications for cribriform prostate cancer and give recommendations for future research.

Keywords: Prostate; cancer; cribriform; pathology.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Contemporary Gleason grading patterns, hematoxylin and eosin stain, 200× magnification. (A) Well-delineated glands (Gleason grade 3); (B) fused pattern (Gleason grade 4); (C) ill-formed pattern (Gleason grade 4); (D) glomeruloid pattern (Gleason grade 4); (E) cribriform pattern (Gleason grade 4); (F) solid pattern (Gleason grade 5); (G) comedonecrosis (Gleason grade 5); (H) single cells (Gleason grade 5).
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