Chemistry and biochemistry of metallothionein
- PMID: 2959513
- DOI: 10.1007/978-3-0348-6784-9_3
Chemistry and biochemistry of metallothionein
Abstract
A wealth of chemical, spectroscopic and structural data attest to the uniqueness of the metallothioneins as a group of novel bioinorganic structures. Their earmarking feature is the arrangement of "soft" metal ions in complexes with cysteine side chains to form discrete metal-thiolate clusters. In this review an account is given of the chemical characteristics of the 52 metallothioneins whose primary structures are now known completely or in part. Also included is an up-to-date summary of the spectroscopic properties and of the spatial structure models derived from X-ray diffraction crystallographic analysis and from two-dimensional nuclear magnetic resonance spectroscopy.
Similar articles
-
Model for mammalian metallothionein structure.Proc Natl Acad Sci U S A. 1983 Mar;80(6):1501-5. doi: 10.1073/pnas.80.6.1501. Proc Natl Acad Sci U S A. 1983. PMID: 6572910 Free PMC article.
-
Refined crystal structure of Cd, Zn metallothionein at 2.0 A resolution.J Mol Biol. 1991 Oct 20;221(4):1269-93. J Mol Biol. 1991. PMID: 1942051
-
Advances in the structure and chemistry of metallothioneins.J Inorg Biochem. 2002 Feb;88(3-4):388-96. doi: 10.1016/s0162-0134(01)00347-6. J Inorg Biochem. 2002. PMID: 11897355 Review.
-
Structure of mammalian metallothionein.Environ Health Perspect. 1984 Mar;54:93-103. doi: 10.1289/ehp.54-1568188. Environ Health Perspect. 1984. PMID: 6329671 Free PMC article.
-
The metallothionein structural motif in gene expression.Adv Inorg Biochem. 1994;10:1-48. Adv Inorg Biochem. 1994. PMID: 8203284 Review.
Cited by
-
Primary structure and tissue-specific expression of blue crab (Callinectes sapidus) metallothionein isoforms.Biochem J. 1995 Oct 15;311 ( Pt 2)(Pt 2):617-22. doi: 10.1042/bj3110617. Biochem J. 1995. PMID: 7487904 Free PMC article.
-
Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals.Environ Health Perspect. 1998 Dec;106(12):825-31. doi: 10.1289/ehp.98106825. Environ Health Perspect. 1998. PMID: 9831543 Free PMC article.
-
The effect of multiwalled carbon nanotubes on hepatotoxicity of Cd2+ in accumulated cadmium-metallothione in mice.Biomed Res Int. 2014;2014:463161. doi: 10.1155/2014/463161. Epub 2014 Sep 2. Biomed Res Int. 2014. PMID: 25276789 Free PMC article.
-
Analysis of Metal-Binding Features of the Wild Type and Two Domain-Truncated Mutant Variants of Littorina littorea Metallothionein Reveals Its Cd-Specific Character.Int J Mol Sci. 2017 Jul 6;18(7):1452. doi: 10.3390/ijms18071452. Int J Mol Sci. 2017. PMID: 28684668 Free PMC article.
-
ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein gene.Mol Cell Biol. 1988 Jul;8(7):2745-52. doi: 10.1128/mcb.8.7.2745-2752.1988. Mol Cell Biol. 1988. PMID: 3043194 Free PMC article.