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. 2018 Jun;46(6):2177-2185.
doi: 10.1177/0300060517748842. Epub 2018 Mar 29.

Serum neutrophil gelatinase-associated lipocalin and cystatin C are diagnostic markers of renal dysfunction in older patients with coronary artery disease

Hong Zhu  1 , Yuying Qian  1
Affiliations

Serum neutrophil gelatinase-associated lipocalin and cystatin C are diagnostic markers of renal dysfunction in older patients with coronary artery disease

Hong Zhu et al. J Int Med Res. 2018 Jun.

Abstract

Objective This study aimed to assess the diagnostic value of serum neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C for renal dysfunction in older patients with coronary disease. Methods A total of 84 older patients with coronary artery disease were included in this study. Serum NGAL and cystatin C levels were analysed using commercially available kits. Medical data of all patients were recorded and analysed. Results NGAL and cystatin C levels were significantly positively correlated with N-terminal prohormone of brain natriuretic peptide levels and negatively correlated with the estimated glomerular filtration rate. The areas under the receiver operating characteristic curves of serum NGAL and cystatin C levels for diagnosing early renal dysfunction were 0.884 and 0.744, respectively. Conclusion Serum NGAL and cystatin C are potential early and sensitive markers of renal dysfunction in older patients with coronary artery disease.

Keywords: Neutrophil gelatinase-associated lipocalin (NGAL); chronic heart failure; coronary artery; cystatin C; older patient; renal function.

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Figures

Figure 1.
Figure 1.
Scatter plots showing correlations of serum NGAL or cystatin C with NT-proBNP or the eGFR (a) Correlation of serum NGAL with NTproBNP levels; (b) correlation of serum NGAL levels with the eGFR; (c) correlation of serum cystatin C with NT-proBNP levels; and (d) correlation of serum cystatin C levels with the eGFR. NGAL, neutrophil gelatinase-associated lipocalin; NT-proBNP, N-terminal prohormone of brain natriuretic peptide; eGFR, estimated glomerular filtration rate.
Figure 2.
Figure 2.
ROC curves of serum NGAL and cystatin C levels for diagnosing renal dysfunction ROC, receiver operating characteristic; NGAL, neutrophil gelatinase-associated lipocalin.
See this image and copyright information in PMC

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