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Meta-Analysis
. 2018 Mar;97(13):e0126.
doi: 10.1097/MD.0000000000010126.

Evidence-based practice guideline of Chinese herbal medicine for primary open-angle glaucoma (qingfeng -neizhang)

Yingxin Yang  1 , Qiu-Yan Ma, Yue Yang, Yu-Peng He, Chao-Ting Ma, Qiang Li, Ming Jin, Wei Chen
Affiliations
Meta-Analysis

Evidence-based practice guideline of Chinese herbal medicine for primary open-angle glaucoma (qingfeng -neizhang)

Yingxin Yang et al. Medicine (Baltimore). 2018 Mar.

Abstract

Background: Primary open angle glaucoma (POAG) is a chronic, progressive optic neuropathy. The aim was to develop an evidence-based clinical practice guideline of Chinese herbal medicine (CHM) for POAG with focus on Chinese medicine pattern differentiation and treatment as well as approved herbal proprietary medicine.

Methods: The guideline development group involved in various pieces of expertise in contents and methods. Authors searched electronic databases include CNKI, VIP, Sino-Med, Wanfang data, PubMed, the Cochrane Library, EMBASE, as well as checked China State Food and Drug Administration (SFDA) from the inception of these databases to June 30, 2015. Systematic reviews and randomized controlled trials of Chinese herbal medicine treating adults with POAG were evaluated. Risk of bias tool in the Cochrane Handbook and evidence strength developed by the GRADE group were applied for the evaluation, and recommendations were based on the findings incorporating evidence strength. After several rounds of Expert consensus, the final guideline was endorsed by relevant professional committees.

Results: CHM treatment principle and formulae based on pattern differentiation together with approved patent herbal medicines are the main treatments for POAG, and the diagnosis and treatment focusing on blood related patterns is the major domain.

Conclusion: CHM therapy alone or combined with other conventional treatment reported in clinical studies together with Expert consensus were recommended for clinical practice.

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Conflict of interest statement

Funding/support: Open-angle glaucoma (Qingfeng Neizhang) guideline was developed by Beijing Traditional Chinese Medicine Hospital, Capital Medical University, which was commissioned by ophthalmic branch of China Association of Traditional Chinese Medicine. It was funded by the project titled “Guidelines for clinical diagnosis and treatment of Traditional Chinese Medicine (Revision) for POAG” [project number: SATCM-2015-BZ (009)] sponsored by State Administration of Traditional Chinese Medicine and was partially funded by the grant number 7152071 by the Beijing Natural Science Foundation and the grant number 15ZY09 by the Capital Medical University. All members of the guideline development team stated that the preparation of the guideline would be fully independent, there was no conflict of interest among the members of the guideline working team, no fund from drug and device makers, the drugs used were not affected by any manufacturer, and no contact with any interest groups.

The authors have no conflicts of interest statement.

Figures

Figure 1
Figure 1
PRISMA 2009 flow Diagram. Note: ∗Records identified through database searching (n = 581): The Chinese literatures included 138 articles from Wanfang database, 91 from VIP database, 300 from CNKI, 52 from CBM. †Records excluded (n = 288): Through reading the title and abstract, a total of 288 articles were excluded. There were 85 articles unrelated to interventions, 72 articles failed to conform to the articles, 41 articles were not complied with, and 90 articles were not studied.
See this image and copyright information in PMC

References

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