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Review
. 2018 Apr;141(4):586e-599e.
doi: 10.1097/PRS.0000000000004262.

How to Diagnose and Treat Breast Implant-Associated Anaplastic Large Cell Lymphoma

Mark W Clemens  1   2 , Garry S Brody  1   2 , Raman C Mahabir  1   2 , Roberto N Miranda  1   2
Affiliations
Review

How to Diagnose and Treat Breast Implant-Associated Anaplastic Large Cell Lymphoma

Mark W Clemens et al. Plast Reconstr Surg. 2018 Apr.

Abstract

Learning objectives: After reading this article, the participant should be able to: 1. Describe the diagnostic criteria for breast implant-associated (BIA) anaplastic large cell lymphoma (ALCL). 2. Appropriately evaluate a patient with suspected BIA-ALCL, including appropriate imaging, laboratory tests, and pathologic evaluation. 3. Understand the operative treatment of BIA-ALCL, and indications for systemic chemotherapy and/or radiation therapy in advanced disease. 4. Understand treatment outcomes and prognosis based on stage of disease.

Summary: The goal of this continuing medical education module is to present the assessment of a patient with suspected breast implant-associated anaplastic large cell lymphoma, the evaluation and diagnosis, the preoperative oncologic workup, the formation and execution of a surgical treatment plan, and the inclusion of adjunct treatments when indicated. In addition, staging and disease progression for treatment of breast implant-associated anaplastic large cell lymphoma are discussed.

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References

    1. U.S. Food and Drug Administration. Anaplastic large cell lymphoma (ALCL): Preliminary FDA findings and analyses. Available at: www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/ImplantsandProst.... Accessed March 20, 2017.
    1. Clemens MW, Miranda RNComing of age: Breast implant-associated anaplastic large cell lymphoma after 18 years of investigation. Clin Plast Surg. 2015;42:605613.
    1. Ramos-Gallardo G, Cuenca-Pardo J, Rodríguez-Olivares E, et al.Breast implant and anaplastic large cell lymphoma meta-analysis. J Invest Surg. 2016;18:110.
    1. Gidengil CA, Predmore Z, Mattke S, van Busum K, Kim BBreast implant-associated anaplastic large cell lymphoma: A systematic review. Plast Reconstr Surg. 2015;135:713720.
    1. Clemens MW, Nava MB, Rocco N, Miranda RNUnderstanding rare adverse sequelae of breast implants: Anaplastic large-cell lymphoma, late seromas, and double capsules. Gland Surg. 2017;6:169184.

MeSH terms