Germline Editing: Editors Cautionary
- PMID: 29595865
- DOI: 10.7417/T.2018.2053
Germline Editing: Editors Cautionary
Abstract
This communication is regarding the recent editing of the genome of the human embryo with CRISPR/Cas9 which generated a debate amongst the biological scientists around the world. Editing human germline genes may act as godsend in some serious genetic and other disorders as the genes related to these disorders can be replaced effectively. The scientists are in dilemma whether the human germline gene modification is a boon or bane for the human society. Though editing human germline genes may be an answer to many serious genetic disorders however; it may have unpredictable effects on future generations. The ethical issues regarding the germline editing need further discussion which may have implications on human race and on-going human evolution. Thus, the researchers need to be doubly cautious and some stringent regulations should be framed regarding the various aspects of germ line gene modifications and any potential conflict with nature for future outcome.
Keywords: Ethics; Gene; Human germline editing; Human society.
Similar articles
-
Human Genome Editing and Ethical Considerations.Sci Eng Ethics. 2016 Apr;22(2):597-9. doi: 10.1007/s11948-015-9675-8. Epub 2015 Jul 8. Sci Eng Ethics. 2016. PMID: 26154417
-
New gene editing technique CRISPR-Cas9 raises important ethical questions, says advisory body.BMJ. 2016 Sep 30;354:i5318. doi: 10.1136/bmj.i5318. BMJ. 2016. PMID: 27694221 No abstract available.
-
The ethics of creating genetically modified children using genome editing.Curr Opin Endocrinol Diabetes Obes. 2017 Dec;24(6):418-423. doi: 10.1097/MED.0000000000000369. Curr Opin Endocrinol Diabetes Obes. 2017. PMID: 28885275 Review.
-
Genome Editing: The Recent History and Perspective in Cardiovascular Diseases.J Am Coll Cardiol. 2017 Dec 5;70(22):2808-2821. doi: 10.1016/j.jacc.2017.10.002. J Am Coll Cardiol. 2017. PMID: 29191331 Free PMC article. Review.
-
The case for germline gene correction: state of the science.Fertil Steril. 2025 Jul;124(1):22-29. doi: 10.1016/j.fertnstert.2025.04.039. Epub 2025 May 5. Fertil Steril. 2025. PMID: 40334730 Review.
Cited by
-
Genome-Editing Technologies: Concept, Pros, and Cons of Various Genome-Editing Techniques and Bioethical Concerns for Clinical Application.Mol Ther Nucleic Acids. 2019 Jun 7;16:326-334. doi: 10.1016/j.omtn.2019.02.027. Epub 2019 Apr 3. Mol Ther Nucleic Acids. 2019. PMID: 30965277 Free PMC article. Review.
-
A Landscape of CRISPR/Cas Technique for Emerging Viral Disease Diagnostics and Therapeutics: Progress and Prospects.Pathogens. 2022 Dec 29;12(1):56. doi: 10.3390/pathogens12010056. Pathogens. 2022. PMID: 36678404 Free PMC article. Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical