Non-Coding RNAs and Endometrial Cancer

doi:10.3390/genes9040187

Review

. 2018 Mar 29;9(4):187.

doi: 10.3390/genes9040187.

Non-Coding RNAs and Endometrial Cancer

Cristina Vallone¹, Giuliano Rigon², Caterina Gulia³, Alberto Baffa⁴, Raffaella Votino⁵, Giulia Morosetti⁶, Simona Zaami⁷, Vito Briganti⁸, Francesco Catania⁹, Marco Gaffi¹⁰, Roberto Nucciotti¹¹, Fabio Massimo Costantini¹¹, Roberto Piergentili¹², Lorenza Putignani^{13

14}, Fabrizio Signore¹⁵

Affiliations

¹ Department of Obstetrics and Gynaecology, Misericordia Hospital Grosseto, Usl Sud-Est Toscana, 58100 Grosseto, Italy. cristina.vallone@uslsudest.toscana.it.
² Department of Obstetrics and Gynaecology, San Camillo-Forlanini Hospital, 00152 Rome, Italy. grigon@scamilloforlanini.rm.it.
³ Department of Pediatric Surgery and Urology, San Camillo-Forlanini Hospital, 00152 Rome, Italy. 85cate@live.it.
⁴ Department of Obstetrics and Gynaecology, Misericordia Hospital Grosseto, Usl Sud-Est Toscana, 58100 Grosseto, Italy. alberto.baffa@uslsudest.toscana.it.
⁵ Department of Obstetrics and Gynaecology, Misericordia Hospital Grosseto, Usl Sud-Est Toscana, 58100 Grosseto, Italy. raffaella.votino@uslsudest.toscana.it.
⁶ Department of Obstetrics and Gynaecology, Misericordia Hospital Grosseto, Usl Sud-Est Toscana, 58100 Grosseto, Italy. giuliamorosetti@gmail.com.
⁷ Unit of Forensic Toxicology (UoFT), Department of Anatomical Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00185 Roma, Italy. simona.zaami@uniroma1.it.
⁸ Department of Pediatric Surgery and Urology, San Camillo-Forlanini Hospital, 00152 Rome, Italy. vito.briganti@fastwebnet.it.
⁹ Department of Obstetrics and Gynaecology, Santa Maria alla Gruccia Hospital Valdarno, Usl Sud-Est Toscana, 52025 Montevarchi, Italy. simona.zaami@uniroma1.it.
¹⁰ Department of Urology, San Camillo-Forlanini Hospital, 00152 Rome, Italy. marco.gaffi59@gmail.com.
¹¹ Department of Urology, Misericordia Hospital Grosseto, Usl Sud-Est Toscana, 58100 Grosseto, Italy. roberto.nucciotti@uslsudest.toscana.it.
¹² Institute of Molecular Biology and Pathology, Italian National Research Council, 00185 Rome, Italy. roberto.piergentili@uniroma1.it.
¹³ Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy. lorenza.putignani@opbg.net.
¹⁴ Unit of Parasitology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy. lorenza.putignani@opbg.net.
¹⁵ Department of Obstetrics and Gynaecology, Misericordia Hospital Grosseto, Usl Sud-Est Toscana, 58100 Grosseto, Italy. fabrizio.signore@uslsudest.toscana.it.

PMID: 29596364
PMCID: PMC5924529
DOI: 10.3390/genes9040187

Review

Non-Coding RNAs and Endometrial Cancer

Cristina Vallone et al. Genes (Basel). 2018.

. 2018 Mar 29;9(4):187.

doi: 10.3390/genes9040187.

Authors

Affiliations

¹ Department of Obstetrics and Gynaecology, Misericordia Hospital Grosseto, Usl Sud-Est Toscana, 58100 Grosseto, Italy. cristina.vallone@uslsudest.toscana.it.
² Department of Obstetrics and Gynaecology, San Camillo-Forlanini Hospital, 00152 Rome, Italy. grigon@scamilloforlanini.rm.it.
³ Department of Pediatric Surgery and Urology, San Camillo-Forlanini Hospital, 00152 Rome, Italy. 85cate@live.it.
⁴ Department of Obstetrics and Gynaecology, Misericordia Hospital Grosseto, Usl Sud-Est Toscana, 58100 Grosseto, Italy. alberto.baffa@uslsudest.toscana.it.
⁵ Department of Obstetrics and Gynaecology, Misericordia Hospital Grosseto, Usl Sud-Est Toscana, 58100 Grosseto, Italy. raffaella.votino@uslsudest.toscana.it.
⁶ Department of Obstetrics and Gynaecology, Misericordia Hospital Grosseto, Usl Sud-Est Toscana, 58100 Grosseto, Italy. giuliamorosetti@gmail.com.
⁷ Unit of Forensic Toxicology (UoFT), Department of Anatomical Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00185 Roma, Italy. simona.zaami@uniroma1.it.
⁸ Department of Pediatric Surgery and Urology, San Camillo-Forlanini Hospital, 00152 Rome, Italy. vito.briganti@fastwebnet.it.
⁹ Department of Obstetrics and Gynaecology, Santa Maria alla Gruccia Hospital Valdarno, Usl Sud-Est Toscana, 52025 Montevarchi, Italy. simona.zaami@uniroma1.it.
¹⁰ Department of Urology, San Camillo-Forlanini Hospital, 00152 Rome, Italy. marco.gaffi59@gmail.com.
¹¹ Department of Urology, Misericordia Hospital Grosseto, Usl Sud-Est Toscana, 58100 Grosseto, Italy. roberto.nucciotti@uslsudest.toscana.it.
¹² Institute of Molecular Biology and Pathology, Italian National Research Council, 00185 Rome, Italy. roberto.piergentili@uniroma1.it.
¹³ Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy. lorenza.putignani@opbg.net.
¹⁴ Unit of Parasitology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy. lorenza.putignani@opbg.net.
¹⁵ Department of Obstetrics and Gynaecology, Misericordia Hospital Grosseto, Usl Sud-Est Toscana, 58100 Grosseto, Italy. fabrizio.signore@uslsudest.toscana.it.

PMID: 29596364
PMCID: PMC5924529
DOI: 10.3390/genes9040187

Abstract

Non-coding RNAs (ncRNAs) are involved in the regulation of cell metabolism and neoplastic transformation. Recent studies have tried to clarify the significance of these information carriers in the genesis and progression of various cancers and their use as biomarkers for the disease; possible targets for the inhibition of growth and invasion by the neoplastic cells have been suggested. The significance of ncRNAs in lung cancer, bladder cancer, kidney cancer, and melanoma has been amply investigated with important results. Recently, the role of long non-coding RNAs (lncRNAs) has also been included in cancer studies. Studies on the relation between endometrial cancer (EC) and ncRNAs, such as small ncRNAs or micro RNAs (miRNAs), transfer RNAs (tRNAs), ribosomal RNAs (rRNAs), antisense RNAs (asRNAs), small nuclear RNAs (snRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), competing endogenous RNAs (ceRNAs), lncRNAs, and long intergenic ncRNAs (lincRNAs) have been published. The recent literature produced in the last three years was extracted from PubMed by two independent readers, which was then selected for the possible relation between ncRNAs, oncogenesis in general, and EC in particular.

Keywords: endometrial cancer; epigenetics; long non-coding RNA (lncRNA); non-coding RNA (ncRNA); small non-coding RNA (small ncRNA).

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Differentially expressed long non-coding RNA (lncRNA), long intergenic non-coding RNAs (lincRNAs) lincRNA and micro RNAs (miRNA) in Endometrial Cancer (EC).

See this image and copyright information in PMC

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References

1. Kapranov P., Cheng J., Dike S., Nix D.A., Duttagupta R., Willingham A.T., Stadler P.F., Hertel J., Hackermüller J., Hofacker I.L., et al. RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science. 2007;316:1484–1488. doi: 10.1126/science.1138341. - DOI - PubMed
1. Ma L., Bajic V.B., Zhang Z. On the classification of long non-coding RNAs. RNA Biol. 2013;10:925–933. doi: 10.4161/rna.24604. - DOI - PMC - PubMed
1. Ling H., Vincent K., Pichler M., Fodde R., Berindan-Neagoe I., Slack F.J., Calin G.A. Junk DNA and the long non-coding RNA twist in cancer genetics. Oncogene. 2015;34:5003–5011. doi: 10.1038/onc.2014.456. - DOI - PMC - PubMed
1. Ponjavic J., Ponting C.P., Lunter G. Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. Genome Res. 2007;17:556–565. doi: 10.1101/gr.6036807. - DOI - PMC - PubMed
1. Wang K.C., Chang H.Y. Molecular mechanisms of long noncoding RNAs. Mol. Cell. 2011;43:904–914. doi: 10.1016/j.molcel.2011.08.018. - DOI - PMC - PubMed

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[1] Kapranov P., Cheng J., Dike S., Nix D.A., Duttagupta R., Willingham A.T., Stadler P.F., Hertel J., Hackermüller J., Hofacker I.L., et al. RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science. 2007;316:1484–1488. doi: 10.1126/science.1138341. - DOI - PubMed

[2] Kapranov P., Cheng J., Dike S., Nix D.A., Duttagupta R., Willingham A.T., Stadler P.F., Hertel J., Hackermüller J., Hofacker I.L., et al. RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science. 2007;316:1484–1488. doi: 10.1126/science.1138341. - DOI - PubMed

[3] Ma L., Bajic V.B., Zhang Z. On the classification of long non-coding RNAs. RNA Biol. 2013;10:925–933. doi: 10.4161/rna.24604. - DOI - PMC - PubMed

[4] Ma L., Bajic V.B., Zhang Z. On the classification of long non-coding RNAs. RNA Biol. 2013;10:925–933. doi: 10.4161/rna.24604. - DOI - PMC - PubMed

[5] Ling H., Vincent K., Pichler M., Fodde R., Berindan-Neagoe I., Slack F.J., Calin G.A. Junk DNA and the long non-coding RNA twist in cancer genetics. Oncogene. 2015;34:5003–5011. doi: 10.1038/onc.2014.456. - DOI - PMC - PubMed

[6] Ling H., Vincent K., Pichler M., Fodde R., Berindan-Neagoe I., Slack F.J., Calin G.A. Junk DNA and the long non-coding RNA twist in cancer genetics. Oncogene. 2015;34:5003–5011. doi: 10.1038/onc.2014.456. - DOI - PMC - PubMed

[7] Ponjavic J., Ponting C.P., Lunter G. Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. Genome Res. 2007;17:556–565. doi: 10.1101/gr.6036807. - DOI - PMC - PubMed

[8] Ponjavic J., Ponting C.P., Lunter G. Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. Genome Res. 2007;17:556–565. doi: 10.1101/gr.6036807. - DOI - PMC - PubMed

[9] Wang K.C., Chang H.Y. Molecular mechanisms of long noncoding RNAs. Mol. Cell. 2011;43:904–914. doi: 10.1016/j.molcel.2011.08.018. - DOI - PMC - PubMed

[10] Wang K.C., Chang H.Y. Molecular mechanisms of long noncoding RNAs. Mol. Cell. 2011;43:904–914. doi: 10.1016/j.molcel.2011.08.018. - DOI - PMC - PubMed

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Non-Coding RNAs and Endometrial Cancer

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Non-Coding RNAs and Endometrial Cancer

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