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Editorial
. 2018 May 1;114(6):771-772.
doi: 10.1093/cvr/cvy062.

A new strategy to decrease cardiac injury in aged heart following ischaemia-reperfusion: enhancement of the interaction between AMPK and SIRT1

Qun Chen  1 , Edward J Lesnefsky  1   2   3   4
Affiliations
Editorial

A new strategy to decrease cardiac injury in aged heart following ischaemia-reperfusion: enhancement of the interaction between AMPK and SIRT1

Qun Chen et al. Cardiovasc Res. .
No abstract available

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Figures

Figure 1
Figure 1
Activation of SIRT1 and AMPK decreases cardiac injury in aged hearts following IR. Aging and IR decreases SIRT1 activity that leads to decreased AMPK activity through acetylation and subsequent inhibition of LKB1. Deactivation of AMPK also affects SIRT1 activity due to altered NAD+ concentration. Sestrin 2 may also interact and affect AMPK activation. Deactivation of SIRT1 and AMPK leads to decreased glucose oxidation and increased fatty acid oxidation (FAO) that contribute to increased injury in aged hearts following IR. Aging also impairs mtDNA that increases ROS generation by inhibiting Complex III at mitochondrial ETC. IR leads to decreased PDH activity that also leads to altered metabolism in hearts with decreased glucose oxidation and increased FAO. Activation of SIRT1 and AMPK is a promising approach to decrease cardiac injury in aged hearts following IR.
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