Escaping Circadian Regulation: An Emerging Hallmark of Cancer?

Rukeia El-Athman¹, Angela Relógio²

Affiliations

¹ Institute for Theoretical Biology (ITB), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Medical Department of Hematology, Oncology, and Tumor Immunology, and Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
² Institute for Theoretical Biology (ITB), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Medical Department of Hematology, Oncology, and Tumor Immunology, and Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address: angela.relogio@charite.de.

PMID: 29596780
DOI: 10.1016/j.cels.2018.03.006

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Escaping Circadian Regulation: An Emerging Hallmark of Cancer?

Rukeia El-Athman et al. Cell Syst. 2018.

Free article

. 2018 Mar 28;6(3):266-267.

doi: 10.1016/j.cels.2018.03.006.

Authors

Rukeia El-Athman¹, Angela Relógio²

Affiliations

¹ Institute for Theoretical Biology (ITB), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Medical Department of Hematology, Oncology, and Tumor Immunology, and Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
² Institute for Theoretical Biology (ITB), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Medical Department of Hematology, Oncology, and Tumor Immunology, and Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address: angela.relogio@charite.de.

PMID: 29596780
DOI: 10.1016/j.cels.2018.03.006

Abstract

Alterations of circadian clock genes are associated with patient survival, tumor stage, and clinical subtype across various cancer types, highlighting the importance of timing in cancer treatment.

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The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy.
Ye Y, Xiang Y, Ozguc FM, Kim Y, Liu CJ, Park PK, Hu Q, Diao L, Lou Y, Lin C, Guo AY, Zhou B, Wang L, Chen Z, Takahashi JS, Mills GB, Yoo SH, Han L. Ye Y, et al. Cell Syst. 2018 Mar 28;6(3):314-328.e2. doi: 10.1016/j.cels.2018.01.013. Epub 2018 Mar 7. Cell Syst. 2018. PMID: 29525205 Free PMC article.

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Escaping Circadian Regulation: An Emerging Hallmark of Cancer?

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Escaping Circadian Regulation: An Emerging Hallmark of Cancer?

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