Friends with Benefits: Microenvironmental NRG1β and HGF Mediate HER2-Targeted Resistance in L-HER2+ and HER2E Breast Cancer
- PMID: 29596781
- DOI: 10.1016/j.cels.2018.03.005
Friends with Benefits: Microenvironmental NRG1β and HGF Mediate HER2-Targeted Resistance in L-HER2+ and HER2E Breast Cancer
Abstract
Watson et al. use microenvironment microarrays to assess how extrinsic signals within the tumor microenvironment influence HER2++ breast cancer resistance to the HER2-targeted tyrosine kinase inhibitor lapatinib.
Copyright © 2018 Elsevier Inc. All rights reserved.
Comment on
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Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes.Cell Syst. 2018 Mar 28;6(3):329-342.e6. doi: 10.1016/j.cels.2018.02.001. Epub 2018 Mar 14. Cell Syst. 2018. PMID: 29550255 Free PMC article.
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