doi: 10.1016/0165-0327(87)90072-3.
Platelet 5-HT receptor binding during depressive illness and tricyclic antidepressant treatment
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- PMID: 2959699
- DOI: 10.1016/0165-0327(87)90072-3
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Platelet 5-HT receptor binding during depressive illness and tricyclic antidepressant treatment
J Affect Disord.
1987 Jul-Aug.
Abstract
5-Hydroxytryptamine (5-HT) receptor binding was determined in intact human platelets using 125I-iodolysergic acid diethylamide (125I-iodoLSD). The assay revealed that platelets possess a single population of specific binding sites for 125I-iodoLSD which have a high affinity for the 5-HT2 receptor antagonists, ketanserin and spiperone. There was no difference in platelet 125I-iodoLSD receptor binding between depressed patients and controls. However, treatment with tricyclic antidepressants increased the number of 125I-iodoLSD receptor binding sites without significantly altering their affinity.
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