Natural products with anti-aging potential: Affected targets and molecular mechanisms

Abstract

In recent years, there has been a great deal of attention toward the molecular machinery relevant to age-related progression controlled through the external intervention of polyphenols- an epigenetic-modulating diet. Natural products modulate cellular longevity through histone post-translational modification and can also induce the upregulation of autophagy, thus reducing the level of acetyl coenzyme A (AcCoA). In addition, the effect of caloric restriction (CR) on cancer-related chronic inflammation is of great significance in aging. In line with this, SIRT1 protein levels are expanded in response to calorie restriction mimetics (CRM), in this way acting as autophagy inducers relevant to cancer prevention.

Keywords: AMPK1; Aging; Caloric restriction; Histone modifications; NF-kB; Polyphenols; SIRT1; Signaling pathways; Transcription; mTOR.