Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1987 Oct;84(20):7305-9.
doi: 10.1073/pnas.84.20.7305.

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein

T Yoshida  1 , K Miyagawa, H Odagiri, H Sakamoto, P F Little, M Terada, T Sugimura
Affiliations
Comparative Study

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein

T Yoshida et al. Proc Natl Acad Sci U S A. 1987 Oct.

Erratum in

  • Proc Natl Acad Sci U S A 1988 Mar;85(6):1967

Abstract

hst is a transforming gene first identified from transformed NIH 3T3 cells that were transfected with DNA of a human stomach cancer. A genomic fragment of hst obtained directly from a human genomic library also has transforming activity. This fragment has a coding sequence identical to that of the hst cDNA prepared from an NIH 3T3 transformant induced by DNA from a stomach cancer. The deduced amino acid sequence of the hst protein is 43%, 38%, and 40% homologous, respectively, to human basic fibroblast growth factor, human acidic fibroblast growth factor, and mouse int-2 protein in selected regions. This suggests that hst encodes a protein related to fibroblast growth factors, which are wide-spectrum mitogens, and to the int-2 protein, a potential oncogene product implicated in murine mammary carcinogenesis.

PubMed Disclaimer

References

    1. J Biol Chem. 1986 Apr 25;261(12):5631-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Apr;83(8):2448-52 - PubMed
    1. Nature. 1986 May 15-21;321(6067):209-13 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3997-4001 - PubMed
    1. EMBO J. 1986 May;5(5):919-24 - PubMed

Publication types

Associated data