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Review
. 2018 Feb;35(1):18-25.
doi: 10.5114/ada.2018.73160. Epub 2018 Feb 20.

Selected presentations of lip enlargement: clinical manifestation and differentiation

Affiliations
Review

Selected presentations of lip enlargement: clinical manifestation and differentiation

Katarzyna J Błochowiak et al. Postepy Dermatol Alergol. 2018 Feb.

Abstract

Lip enlargement may be an important symptom of either systemic or local diseases. On the basis of selected age-matched clinical cases we present the possible causes of lip swelling. We describe the most representative symptoms and recommend treatment of these pathologies. We differentiate lip swelling in Miescher syndrome, monosymptomatic form of Melkersson-Rosenthal syndrome, lip swelling in erythema multiforme and Stevens-Johnson syndrome and lip hemangioma and mucous extravasation cyst. We compare different causes of lip edema and indicate the most helpful diagnostic and treatment methods.

Keywords: Melkersson-Rosenthal syndrome; Miescher syndrome; Stevens-Johnson syndrome; mucocele.

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Figures

Figure 1
Figure 1
Lip edema in Miescher syndrome [–5]
Figure 2
Figure 2
Enlargement of the lower lip in Miescher syndrome [3, 6, 8]
Figure 3
Figure 3
Erythema multiforme with accompanying severe mucositis and lip swelling [9, 10, 13]
Figure 4
Figure 4
Stevens-Johnson syndrome [9, 13, 14, 18]
Figure 5
Figure 5
Mucocele of the lower lip [23, 24]
Figure 6
Figure 6
Hemangioma of the lower lip [25]

References

    1. Antoszczyk G, Obtułowicz A, Czarnobilska E, et al. Melkersson-Rosenthal syndrome – diagnostic and therapeutic problems. Przeg Lek. 2008;65:390–92. - PubMed
    1. Elias MK, Mateen FJ, Weiler CR. The Melkersson-Rosenthal syndrome: a retrospective study of biopsied cases. J Neurol. 2013;260:138–43. - PubMed
    1. Gonçalves DU, de Castro MM, Galvão CP, et al. Cheilitis granulomatosa associated with Melkersson-Rosenthal syndrome. Braz J Otorhinolaryngol. 2007;73:132–3. - PMC - PubMed
    1. Kruse-Lösler B, Presser D, Metze D, et al. Surgical treatment of persistent macrocheilia in patients with Melkersson-Rosenthal syndrome and cheilitis granulomatosa. Arch Dermatol. 2005;141:1085–91. - PubMed
    1. El-Hakim M, Chauvin P. Orofacial granulomatosis presenting as persistent lip swelling: review of 6 new cases. J Oral Maxillofac Surg. 2004;62:1114–7. - PubMed

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