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Review
. 2018 Mar 1:9:108.
doi: 10.3389/fneur.2018.00108. eCollection 2018.

The Quest for an Alzheimer Therapy

Stefano F Cappa  1   2
Affiliations
Review

The Quest for an Alzheimer Therapy

Stefano F Cappa. Front Neurol. .

Abstract

This mini-review considers three different approaches to the therapy and prevention of Alzheimer's disease (AD): replacement therapy, disease modification, and multi-level interventions. Each of these research frameworks has direct implications at the clinical level, leading to an emphasis on different time points of the AD continuum. While all perspectives continue to play an important role in current efforts to reach the ambitious target of an effective therapy or prevention of AD by 2025, it is clear that novel paradigms are needed, including new models of clinical trial design. This goal can only be accomplished by a concerted effort of academia, governmental agencies, and industry.

Keywords: Alzheimer disease; amyloid; dementia prevention; diagnostic criteria; therapy.

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Figures

Figure 1
Figure 1
A simplified diagram of the possible therapeutic approaches, according to the amyloid cascade hypothesis.
See this image and copyright information in PMC

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References

    1. Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, et al. Defeating Alzheimer’s disease and other dementias: a priority for European science and society. Lancet Neurol (2016) 15(5):455–532.10.1016/S1474-4422(16)00062-4 - DOI - PubMed
    1. Cummings J, Aisen PS, DuBois B, Frölich L, Jack CR, Jones RW, et al. Drug development in Alzheimer’s disease: the path to 2025. Alzheimers Res Ther (2016) 8(1):39.10.1186/s13195-016-0207-9 - DOI - PMC - PubMed
    1. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer’s disease. Neurology (1984) 34:939–44.10.1212/WNL.34.7.939 - DOI - PubMed
    1. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement (2011) 7(3):270–9.10.1016/j.jalz.2011.03.008 - DOI - PMC - PubMed
    1. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Jr, Kawas CH, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement (2011) 7(3):263–9.10.1016/j.jalz.2011.03.005 - DOI - PMC - PubMed

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