Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jul 3;14(7):1697-1716.
doi: 10.1080/21645515.2018.1458806. Epub 2018 May 14.

The current status, challenges, and future developments of new tuberculosis vaccines

Wenping Gong  1 , Yan Liang  1 , Xueqiong Wu  1
Affiliations
Review

The current status, challenges, and future developments of new tuberculosis vaccines

Wenping Gong et al. Hum Vaccin Immunother. .

Abstract

Mycobacterium tuberculosis complex causes tuberculosis (TB), one of the top 10 causes of death worldwide. TB results in more fatalities than multi-drug resistant (MDR) HIV strain related coinfection. Vaccines play a key role in the prevention and control of infectious diseases. Unfortunately, the only licensed preventive vaccine against TB, bacilli Calmette-Guérin (BCG), is ineffective for prevention of pulmonary TB in adults. Therefore, it is very important to develop novel vaccines for TB prevention and control. This literature review provides an overview of the innate and adaptive immune response during M. tuberculosis infection, and presents current developments and challenges to novel TB vaccines. A comprehensive understanding of vaccines in preclinical and clinical studies provides extensive insight for the development of safer and more efficient vaccines, and may inspire new ideas for TB prevention and treatment.

Keywords: BCG; Clinical trials; Immunology; Mycobacterium tuberculosis; Tuberculosis; Vaccines.

PubMed Disclaimer

References

    1. Comas I, Coscolla M, Luo T, Borrell S, Holt KE, Kato-Maeda M, Parkhill J, Malla B, Berg S, Thwaites G, et al. Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans. Nat Genet. 2013;45:1176–82. doi: 10.1038/ng.2744. PMID:23995134 - DOI - PMC - PubMed
    1. WHO Global tuberculosis report 2017. Geneva: World Health Organization, 2017.
    1. Prabowo SA, Groschel MI, Schmidt ED, Skrahina A, Mihaescu T, Hasturk S, Mitrofanov R, Pimkina E, Visontai I, de Jong B, et al. Targeting multidrug-resistant tuberculosis (MDR-TB) by therapeutic vaccines. Med Microbiol Immunol. 2013;202:95–104. doi: 10.1007/s00430-012-0278-6. PMID:23143437 - DOI - PubMed
    1. White AD, Sibley L, Dennis MJ, Gooch K, Betts G, Edwards N, Reyes-Sandoval A, Carroll MW, Williams A, Marsh PD, et al. Evaluation of the Safety and Immunogenicity of a Candidate Tuberculosis Vaccine, MVA85A, Delivered by Aerosol to the Lungs of Macaques. Clin Vaccine Immunol Cvi. 2013;20:663. doi: 10.1128/CVI.00690-12. - DOI - PMC - PubMed
    1. Hussey G, Hawkridge T, Hanekom W. Childhood tuberculosis: old and new vaccines. Paediatr Respir Rev. 2007;8:148–54. doi: 10.1016/j.prrv.2007.04.009. PMID:17574159 - DOI - PubMed

Publication types

LinkOut - more resources