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. 1987:17B:981-5.

Tumor cell-platelet-endothelial cell interactions and prostaglandin metabolism

K V Honn  1 , D G Menter, J M Onoda, B W Steinert, C A Diglio, J D Taylor, B F Sloane
Affiliations
  • PMID: 2960216

Tumor cell-platelet-endothelial cell interactions and prostaglandin metabolism

K V Honn et al. Adv Prostaglandin Thromboxane Leukot Res. 1987.

Abstract

We have proposed that tumor cell induction of platelet aggregation facilitates tumor cell attachment to endothelium and that this attachment is limited by endogenous PGI2. We have developed an in vitro model to study tumor cell-platelet-endothelial cell interactions in which endothelial cells are grown on microcarrier beads. Untreated endothelial cells inhibit tumor cell-induced platelet aggregation, as well as tumor cell attachment to endothelial cells. Inhibition of endothelial cell PGI2 production by indomethacin obviates this inhibition.

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