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Review
. 2018 Jul;12(4):585-590.
doi: 10.1016/j.dsx.2018.03.012. Epub 2018 Mar 22.

Preventing the development and progression of diabetic kidney disease: Where do we stand?

Georgios Zagkotsis  1 , Maria Markou  2 , Eleni Paschou  3 , Panagiota Papanikolaou  4 , Nikos Sabanis  5
Affiliations
Review

Preventing the development and progression of diabetic kidney disease: Where do we stand?

Georgios Zagkotsis et al. Diabetes Metab Syndr. 2018 Jul.

Abstract

Diabetic kidney disease (DKD) is a major factor associated with increased cardiovascular (CV) and all-cause mortality and morbidity in patients with diabetes. Current standard therapy includes intensive management of hyperglycemia and blood pressure control with renin-angiotensin-aldosterone system (RAAS) blockers. Despite the implementation of this strategy, DKD remains the leading cause of end-stage renal disease (ESRD), mainly because of the increasing burden of diabetes mellitus. The aim of this review is to evaluate the available evidence, focusing on the benefit of current treatment in the development and progression of DKD.

Keywords: Blood pressure; Diabetes mellitus; Diabetic kidney disease; Glycemic control; RAAS inhibitors; SGLT-2 inhibitors.

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