Response: Comparing the dosages of lacosamide, eslicarbazepine acetate, and controlled-release carbamazepine in noninferiority epilepsy monotherapy trials: How much "fair" is "fair"

Eugen Trinka^{1

2

3}, José Francisco Rocha⁴, Patrício Soares-da-Silva^{4

5

6}

Affiliations

¹ Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University Salzburg, Salzburg, Austria.
² Center for Cognitive Neuroscience, Salzburg, Austria.
³ Department of Public Health and Health Technology Assessment, University for Health Sciences, Medical Informatics, and Technology, Hall in Tirol, Austria.
⁴ Department of Research and Development, BIAL-Portela & Cª, Coronado, Portugal.
⁵ Pharmacology and Therapeutics Unit, Department of Biomedicine, Faculty of Medicine, University Porto, Porto, Portugal.
⁶ MedInUP, Center for Drug Discovery and Innovative Medicines, University Porto, Porto, Portugal.

Comment

Eugen Trinka et al. Epilepsia. 2018 Apr.

. 2018 Apr;59(4):900-901.

doi: 10.1111/epi.14062.

Eugen Trinka^{1

2

3}, José Francisco Rocha⁴, Patrício Soares-da-Silva^{4

5

6}

¹ Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University Salzburg, Salzburg, Austria.
² Center for Cognitive Neuroscience, Salzburg, Austria.
³ Department of Public Health and Health Technology Assessment, University for Health Sciences, Medical Informatics, and Technology, Hall in Tirol, Austria.
⁴ Department of Research and Development, BIAL-Portela & Cª, Coronado, Portugal.
⁵ Pharmacology and Therapeutics Unit, Department of Biomedicine, Faculty of Medicine, University Porto, Porto, Portugal.
⁶ MedInUP, Center for Drug Discovery and Innovative Medicines, University Porto, Porto, Portugal.

No abstract available

Comment on

Efficacy and safety of eslicarbazepine acetate versus controlled-release carbamazepine monotherapy in newly diagnosed epilepsy: A phase III double-blind, randomized, parallel-group, multicenter study.
Trinka E, Ben-Menachem E, Kowacs PA, Elger C, Keller B, Löffler K, Rocha JF, Soares-da-Silva P. Trinka E, et al. Epilepsia. 2018 Feb;59(2):479-491. doi: 10.1111/epi.13993. Epub 2018 Jan 25. Epilepsia. 2018. PMID: 29369348 Clinical Trial.
Comparing the dosages of lacosamide, eslicarbazepine acetate, and controlled-release carbamazepine in noninferiority epilepsy monotherapy trials: How much "fair" is "fair"?
Brigo F, Lattanzi S. Brigo F, et al. Epilepsia. 2018 Apr;59(4):899-900. doi: 10.1111/epi.14035. Epilepsia. 2018. PMID: 29604068 No abstract available.