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Review
. 2018 May;23(5):374-378.
doi: 10.1016/j.tplants.2018.03.003. Epub 2018 Mar 28.

CRISPR/Cas13 as a Tool for RNA Interference

Zahir Ali  1 , Ahmed Mahas  1 , Magdy Mahfouz  2
Affiliations
Review

CRISPR/Cas13 as a Tool for RNA Interference

Zahir Ali et al. Trends Plant Sci. 2018 May.

Abstract

Almost all biological processes involve RNA, making it crucial to develop tools for manipulation of the transcriptome. The bacterial CRISPR/Cas13 system was recently rewired to facilitate RNA manipulation in eukaryotes, including plants. We discuss here the opportunities and limitations of using CRISPR/Cas13 in plants for various types of RNA manipulation.

Keywords: CRISPR/Cas13; RNA manipulation; transcriptome regulation; viral interference.

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