Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Apr 2;18(1):145.
doi: 10.1186/s12879-018-3051-7.

Prevalence of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Treponema pallidum infections in hospitalized patients before transfusion in Xiangya hospital Central South University, China from 2011 to 2016

Wei-Wei Cao  1 , Rong-Rong Zhou  2 , Xinghua Ou  3 , Ling-Xi Shi  1 , Chao-Qi Xiao  1 , Ting-Yin Chen  4 , Hua Tan  5 , Xue-Gong Fan  2 , Bi-Juan Li  1 , Ning Li  6
Affiliations

Prevalence of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Treponema pallidum infections in hospitalized patients before transfusion in Xiangya hospital Central South University, China from 2011 to 2016

Wei-Wei Cao et al. BMC Infect Dis. .

Abstract

Background: Human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Treponema pallidum (TP) infections are considered classic transfusion-transmissible infections (TTIs). Few data are available about the prevalence of TTIs in patients before blood transfusion in China. This study aimed to investigate the seroprevalence of four TTIs among patients before blood transfusion in Xiangya Hospital Central South University, China.

Methods: From 2011 to 2016, 442,121 hospitalized patients before possible blood transfusion were tested for hepatitis B surface antigen (HBsAg), anti-HCV, syphilis antibody (anti-TP) and anti-HIV.

Results: Of the 442,121 patients, the overall positivity of the four TTI serum markers was 15.35%. The positive rates of HBsAg, anti-HCV, anti-HIV and anti-TP were 10.98, 1.43, 0.16 and 2.78%, respectively. TTI serum markers showed a significant difference by gender, with positive rates of 17.98% for males and 12.79% for females. The prevalence of TTI serum markers varied significantly by age. The overall co-infection rate was 0.63%, and the top three multiple infections were HBV-TP, HBV-HCV, and HCV-TP. The co-infection rates of HBV-TP and HBV-HCV showed a significant decrease from 2011 to 2016, while the rates of other co-infections remained stable.

Conclusions: The prevalence of TTIs in patients before blood transfusion is much higher compared to that in blood donors in the region. The infection rates of HIV and TP increased, and the infection rate of HBsAg decreased in recent years.

Keywords: Blood transfusion; Human immunodeficiency virus; Transfusion-transmissible infections; Treponema pallidum; Viral hepatitis.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

The study protocol was approved by the “Medical Ethics Committee of the Xiangya Hospital of Centre South University”. Before enrollment, all participants received a brief explanation of the aims, risks and benefits of the study. The participants signed an informed consent form. Consent was obtained from a parent or guardian on behalf of any participants under the age of 16.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Trends of age- related positive rates of HBsAg (panel b), aAnti-HCV (panel c), Aanti-HIV (panel a), and Aanti-TP (panel d), in patients from Xiangya Hospital Central South University, China, 2011–2016
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Seitz R, Heiden M. Quality and safety in blood supply in 2010. Transfus Med Hemother. 2010;37:112–117. doi: 10.1159/000314497. - DOI - PMC - PubMed
    1. Xie DD, Li J, Chen JT, Eyi UM, Matesa RA, Obono MM, et al. Seroprevalence of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and Treponema pallidum infections among blood donors on Bioko Island, Equatorial Guinea. PLoS One. 2015;10:e0139947. doi: 10.1371/journal.pone.0139947. - DOI - PMC - PubMed
    1. Bloch EM, Vermeulen M, Murphy E. Blood transfusion safety in Africa: a literature review of infectious disease and organizational challenges. Transfus Med Rev. 2012;26:164–180. doi: 10.1016/j.tmrv.2011.07.006. - DOI - PMC - PubMed
    1. Flichman DM, Blejer JL, Livellara BI, Re VE, Bartoli S, Bustos JA, et al. Prevalence and trends of markers of hepatitis B virus, hepatitis C virus and human immunodeficiency virus in argentine blood donors. BMC Infect Dis. 2014;14:218. doi: 10.1186/1471-2334-14-218. - DOI - PMC - PubMed
    1. Hou JL, Lai W. The guideline of prevention and treatment for chronic hepatitis B: a 2015 update. Zhonghua Gan Zang Bing Zhi. 2015;23:888–905. - PubMed

Publication types

MeSH terms

Substances