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. 1987 Dec;169(12):5880-3.
doi: 10.1128/jb.169.12.5880-5883.1987.

Mutational analysis of the lambda int gene: DNA sequence of dominant mutations

S E Bear  1 , J B Clemens, L W Enquist, R J Zagursky
Affiliations

Mutational analysis of the lambda int gene: DNA sequence of dominant mutations

S E Bear et al. J Bacteriol. 1987 Dec.

Abstract

We have combined techniques of genetic and physical mapping with rapid DNA sequence analysis to identify the nucleotide change in lambda int mutations. These mutations define two dominant phenotypic classes: (i) recombination that is partially independent of accessory factors, and (ii) inhibition of wild-type Int by missense or nonsense proteins, i.e., negative complementation.

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