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Case Reports
. 2018 Feb 14;10(1):29-34.
doi: 10.1159/000487001. eCollection 2018 Jan-Apr.

Successful Treatment of Inflammatory Linear Verrucous Epidermal Nevus with Concomitant Psoriasis Using Etanercept

Reda Hesham Saifaldeen  1 , Mohammad I Fatani  2 , Badee Baltow  3 , Abdulmajeed S Khan  4
Affiliations
Case Reports

Successful Treatment of Inflammatory Linear Verrucous Epidermal Nevus with Concomitant Psoriasis Using Etanercept

Reda Hesham Saifaldeen et al. Case Rep Dermatol. .

Abstract

Linear psoriasis is a rare form of the disease characterized by the linear distribution of lesions involving dermatome or along Blaschko's lines. Clinically, it may resemble inflammatory linear verrucous epidermal nevus; a combination of history, skin examination, and histopathology are required to ensure correct diagnosis and appropriate therapy. This paper describes a case of a 23-year-old male presenting with unilateral erythematous scaly plaques arranged in a linear path on the left leg. Etanercept was initiated after poor response to adalimumab. Improvement of his psoriasis was noted, with PASI 75 reduction after 24 weeks of treatment. Clinical studies have shown excellent efficacy of etanercept, and our patient well tolerated treatment with etanercept for 52 weeks without any adverse effects.

Keywords: Etanercept; Inflammatory linear verrucous epidermal nevus; Linear psoriasis.

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Figures

Fig. 1
Fig. 1
a Erythematous, scaly plaques involving both legs. b Psoriatic lesions over both elbows.
Fig. 2
Fig. 2
a Hematoxylin and eosin, ×10. Skin punch biopsy from right leg showing psoriasiform hyperplasia with subtle papillomatosis and hyperparakeratosis. b Hematoxylin and eosin, ×40. Skin punch biopsy from the right leg exhibits almost confluent parakeratosis and an absent granular layer with Munro's microabscesses. Some dilated papillary dermal vessels are noted. c Hematoxylin and eosin, ×20. Skin punch biopsy from left leg showing psoriasiform hyperplasia with subtle papillomatosis and hyperparakeratosis. Absent granular layer is evident, with denuded foci. Also seen is a hair follicle with parakeratotic plugging. d Hematoxylin and eosin, ×40. Skin punch biopsy from left leg exhibiting almost confluent parakeratosis and an absent granular layer with Munro's microabscesses.
Fig. 3
Fig. 3
a Improvement of both legs after 52 weeks of treatment with etanercept. b Improvement of both elbows after 52 weeks of treatment with etanercept.
See this image and copyright information in PMC

References

    1. Menter A, Gottlieb A, Feldman SR, Van Voorhees AS, Leonardi CL, Gordon KB, Lebwohl M, Koo JY, Elmets CA, Korman NJ, Beutner KR, Bhushan R. Guidelines of care for the management of psoriasis and psoriatic arthritis: section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. J Am Acad Dermatol. 2008;58:826–850. - PubMed
    1. Naldi L. Epidemiology of psoriasis. Curr Drug Targets Inflamm Allergy. 2004;3:121–128. - PubMed
    1. Happle R. Somatic recombination may explain linear psoriasis. J Med Genet. 1991;28:337. - PMC - PubMed
    1. Al-Fouzan A, Hassab-EI-Naby H, Nanda A. Congenital linear psoriasis: a case report. Pediatr Dermatol. 1990;7:303–306. - PubMed
    1. Griffiths CE, Iaccarino L, Naldi L, Olivieri I, Pipitone N, Salvarani C, Doria A. Psoriasis and psoriatic arthritis: immunological aspects and therapeutic guidelines. Clin Exp Rheumatol. 2006;24:S72–S78. - PubMed

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