Azaspirodecanediones in generalized anxiety disorder: buspirone

Abstract

Buspirone is a new anxiolytic that is structurally unrelated to other psychotropic drugs. The drug is as effective as benzodiazepines for the treatment of generalized anxiety, and superior to placebo. The effect of buspirone on other anxiety disorders, such as panic disorder or post-traumatic stress disorder, remains untested. Although buspirone's mechanism of action is unknown, it clearly does not act on the same receptor systems that are affected by benzodiazepines. Buspirone appears to lack dependence and abuse potential and has little or no sedative effect. In addition, the drug does not potentiate sedative-hypnotic drugs and does not potentiate functional impairment produced by alcohol. Like benzodiazepines, buspirone appears to be safe even when given in very high doses.