Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Mar 8;3(2):e000755.
doi: 10.1136/bmjgh-2018-000755. eCollection 2018.

Surrogate endpoints in global health research: still searching for killer apps and silver bullets?

Madhukar Pai  1 , Samuel G Schumacher  2 , Seye Abimbola  3   4
Affiliations
Editorial

Surrogate endpoints in global health research: still searching for killer apps and silver bullets?

Madhukar Pai et al. BMJ Glob Health. .
No abstract available

Keywords: health systems; public health.

PubMed Disclaimer

Conflict of interest statement

Competing interests: SA is Editor in Chief of BMJ Global Health.

Figures

Figure 1
Figure 1
A framework for outlining the pathways through which new tuberculosis (TB) tests can result in improved patient outcomes. Source: Schumacher et al PLoS ONE 2016 (open access under Creative Commons license).
Figure 2
Figure 2
How patients navigate the diagnostic ecosystem in a fragmented health system in India. Source: Yellapa et al Global Health Action 2017 (open access under Creative Commons license).
See this image and copyright information in PMC

References

    1. Fleming TR, DeMets DL. Surrogate end points in clinical trials: are we being misled? Ann Intern Med 1996;125:605–13. 10.7326/0003-4819-125-7-199610010-00011 - DOI - PubMed
    1. Grimes DA, Schulz KF. Surrogate end points in clinical research: hazardous to your health. Obstet Gynecol 2005;105(5 Pt 1):1114–8. 10.1097/01.AOG.0000157445.67309.19 - DOI - PubMed
    1. Kemp R, Prasad V. Surrogate endpoints in oncology: when are they acceptable for regulatory and clinical decisions, and are they currently overused? BMC Med 2017;15:134 10.1186/s12916-017-0902-9 - DOI - PMC - PubMed
    1. World Health Organization. Policy statement: automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF system. 2011. http://www.who.int/tb/laboratory/roadmap_xpert_mtb_rif_rev23dec2010.pdf - PubMed
    1. Albert H, Nathavitharana RR, Isaacs C, et al. . Development, roll-out and impact of Xpert MTB/RIF for tuberculosis: what lessons have we learnt and how can we do better? Eur Respir J 2016;48:516–25. 10.1183/13993003.00543-2016 - DOI - PMC - PubMed

Publication types

LinkOut - more resources