Platelets promoting tumor metastasis: culprits or victims?

Affiliations

Editorial

Reinhard Buettner. J Thorac Dis. 2018 Feb.

. 2018 Feb;10(2):550-553.

doi: 10.21037/jtd.2017.12.24.

¹ Institute for Pathology, University Hospital Medical Center Cologne, Cologne, Germany.

No abstract available

Conflict of interest statement

Conflicts of Interest: The author has no conflicts of interest to declare.

ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y₁₂ in platelets.
Kamiyama M, Shirai T, Tamura S, Suzuki-Inoue K, Ehata S, Takahashi K, Miyazono K, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H. Kamiyama M, et al. Cell Death Differ. 2017 Dec;24(12):2066-2076. doi: 10.1038/cdd.2017.114. Epub 2017 Jul 28. Cell Death Differ. 2017. PMID: 28753204 Free PMC article.

1. Halsted WS. I. The Results of Operations for the Cure of Cancer of the Breast Performed at the Johns Hopkins Hospital from June, 1889, to January, 1894. Ann Surg 1894;20:497-555. 10.1097/00000658-189407000-00075 - DOI - PMC - PubMed
1. Keynes G. Breast cancer: a case for conservation. Br Med J (Clin Res Ed) 1981;282:1392. 10.1136/bmj.282.6273.1392-a - DOI - PMC - PubMed
1. Gardner LJ, Ward M, Andtbacka RH, et al. Risk factors for development of melanoma brain metastasis and disease progression: a single-center retrospective analysis. Melanoma Res 2017;27:477-484. 10.1097/CMR.0000000000000382 - DOI - PMC - PubMed
1. Li N. Platelets in cancer metastasis: To help the "villain" to do evil. Int J Cancer 2016;138:2078-87. 10.1002/ijc.29847 - DOI - PubMed
1. Leblanc R, Peyruchaud O. Metastasis: new functional implications of platelets and megakaryocytes. Blood 2016;128:24-31. 10.1182/blood-2016-01-636399 - DOI - PubMed