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Editorial
. 2018 Feb;10(2):554-556.
doi: 10.21037/jtd.2018.01.104.

Small cell lung cancer heterogeneity: elevated a Notch above the Rest!

Khaled A Hassan  1
Affiliations
Editorial

Small cell lung cancer heterogeneity: elevated a Notch above the Rest!

Khaled A Hassan. J Thorac Dis. 2018 Feb.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The author has no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Modeling of SCLC tumors, adapted from Lim et al. Three types of cells are present with variable Notch signaling activity. Cells that have Notch receptors only are activated by ligands on neighboring cells and lose their NE features, becoming non-NE cells (pink). These non-NE SCLC cells promote the growth of NE cells that mostly harbor Notch ligands only (blue) except for a small subpopulation that can have both Notch receptors and ligand (purple) and are capable of inducing HES1. Combining chemotherapy or Notch ligands targeted therapy with Notch activity inhibition can manage both the NE cells and the non-NE cells. SCLC, small cell lung cancer; NE, neuroendocrine.
See this image and copyright information in PMC

Comment on

References

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