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Editorial
. 2018 Feb;10(2):560-563.
doi: 10.21037/jtd.2017.12.135.

PNUTS at the crossroads of tumorigenesis and metastasis formation

Nicole Kiweler  1 , Oliver H Krämer  1
Affiliations
Editorial

PNUTS at the crossroads of tumorigenesis and metastasis formation

Nicole Kiweler et al. J Thorac Dis. 2018 Feb.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Estimated ratio of RNA species in mammalian cells. See text for details. ORF, open reading frame.
Figure 2
Figure 2
Regulation of PNUTS pre-RNA splicing and impact on EMT-associated processes. hnRNP, heterogeneous nuclear ribonucleoprotein; lncRNAs, long non-coding RNAs; EMT, epithelial-to-mesenchymal transition.
See this image and copyright information in PMC

Comment on

References

    1. Serviss JT, Johnsson P, Grander D. An emerging role for long non-coding RNAs in cancer metastasis. Front Genet 2014;5:234. 10.3389/fgene.2014.00234 - DOI - PMC - PubMed
    1. Shi T, Gao G, Cao Y. Long Noncoding RNAs as Novel Biomarkers Have a Promising Future in Cancer Diagnostics. Dis Markers 2016;2016:9085195. - PMC - PubMed
    1. Ma L, Bajic VB, Zhang Z. On the classification of long non-coding RNAs. RNA Biol 2013;10:925-33. 10.4161/rna.24604 - DOI - PMC - PubMed
    1. Rupaimoole R, Slack FJ. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov 2017;16:203-22. 10.1038/nrd.2016.246 - DOI - PubMed
    1. Grelet S, Link LA, Howley B, et al. A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression. Nat Cell Biol 2017;19:1105-15. 10.1038/ncb3595 - DOI - PMC - PubMed

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