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. 2018 Feb;10(2):854-860.
doi: 10.21037/jtd.2017.12.107.

Diagnostic accuracy of interferon-gamma in pericardial effusions for tuberculous pericarditis: a meta-analysis

Chao Liu  1 , Yun-Liang Cui  2 , Chun-Mei Ding  3 , Yan-Hua Wu  3 , Hui-Li Li  2 , Xiao-Fei Liu  3 , Zhi-De Hu  3
Affiliations

Diagnostic accuracy of interferon-gamma in pericardial effusions for tuberculous pericarditis: a meta-analysis

Chao Liu et al. J Thorac Dis. 2018 Feb.

Abstract

Background: Several studies have investigated the diagnostic accuracy of tests of pericardial effusion interferon-gamma for tuberculous pericarditis in patients with pericardial effusion, but the results have varied. The aim of this study was to investigate the diagnostic accuracy of interferon-gamma for tuberculous pericarditis using meta-analysis.

Methods: The PubMed and EMBASE databases were searched to identify studies investigating the diagnostic accuracy of tests for interferon-gamma in pericardial effusion for tuberculous pericarditis. The quality of eligible studies was assessed by the revised Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2), and the sensitivities and specificities of interferon-gamma across eligible studies were pooled by a bivariate model.

Results: A total of four studies encompassing 488 subjects were included. The pooled sensitivity, specificity, positive and negative likelihood ratios (NLRs) were 0.97 [95% confidence interval (CI): 0.87-0.99], 0.99 (95% CI: 0.74-1.00), 187 (95% CI: 3-12,542) and 0.03 (95% CI: 0.01-0.14), respectively.

Conclusion: Testing for interferon-gamma in cases of pericardial effusion is adequate for identifying or ruling out tuberculous pericarditis.

Keywords: Interferon-gamma; diagnostic accuracy; sensitivity; specificity; tuberculous pericarditis.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Flowchart of the study selection process.
Figure 2
Figure 2
Sensitivity and specificity of tests for interferon-gamma in the diagnosis of tuberculous pericarditis assessed by forest plots. TP, true positive; FP, false positive; FN, false negative; TN, true negative; CI, confidence interval.
Figure 3
Figure 3
Summary receiver operating characteristic (sROC) curve of interferon-gamma.
See this image and copyright information in PMC

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