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Review
. 2018 Apr-Jun;5(2):137-155.
doi: 10.4103/apjon.apjon_79_17.

Targeted Therapy: Attacking Cancer with Molecular and Immunological Targeted Agents

Gail M Wilkes  1
Affiliations
Review

Targeted Therapy: Attacking Cancer with Molecular and Immunological Targeted Agents

Gail M Wilkes. Asia Pac J Oncol Nurs. 2018 Apr-Jun.

Abstract

Today, personalized cancer therapy with targeted agents has taken center stage, and offers individualized treatment to many. As the mysteries of the genes in a cell's DNA and their specific proteins are defined, advances in the understanding of cancer gene mutations and how cancer evades the immune system have been made. This article provides a basic and simplified understanding of the available (Food and Drug Administration- approved) molecularly and immunologically targeted agents in the USA. Other agents may be available in Asia, and throughout the USA and the world, many more agents are being studied. Nursing implications for drug classes are reviewed.

Keywords: Cancer; immunological; molecular; targeted agents; targeted therapy.

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Conflict of interest statement

There are no conflicts of interest.

References

    1. World Health Association. Cancer Fact Sheet. February. 2017. [Last accessed on 2017 Nov 27]. Available from: http://www.who.int/mediacentre/factsheets/fs297/en/
    1. American Cancer Society. Global Cancer Facts and Figures 3rd ed. American Cancer Society. 2015. [Last retrieved on 2017 Oct 20; Last accessed on 2017 Nov 27]. Available from: https://www.cancer-org/content/dam/cancer.org/research/cancer-facts-and-... .
    1. Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell. 2011;144:646–74. - PubMed
    1. Yu X, Mao W, Zhai Y, Tong C, Liu M, Ma L, et al. Anti-tumor activity of metformin: From metabolic and epigenetic perspectives. Oncotarget. 2017;8:5619–28. - PMC - PubMed
    1. Santarpia L, Lippman SM, El-Naggar AK. Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy. Expert Opin Ther Targets. 2012;16:103–19. - PMC - PubMed