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. 2018 Jun;35(6):1113-1121.
doi: 10.1007/s10815-018-1167-8. Epub 2018 Apr 2.

Impact of high magnification sperm selection on neonatal outcomes: a retrospective study

Olivier Gaspard  1 , Pierre Vanderzwalmen  2 , Barbara Wirleitner  2 , Stéphanie Ravet  3 , Frédéric Wenders  3 , Verena Eichel  2 , Alice Mocková  4 , Dietmar Spitzer  5 , Caroline Jouan  3 , Virginie Gridelet  3   6 , Henri Martens  6 , Laurie Henry  3 , Herbert Zech  2   5 , Sophie Perrier d'Hauterive  3 , Michelle Nisolle  3
Affiliations

Impact of high magnification sperm selection on neonatal outcomes: a retrospective study

Olivier Gaspard et al. J Assist Reprod Genet. 2018 Jun.

Abstract

Purpose: The aim of this study was to compare the effect of the deselection of spermatozoa presenting vacuole-like structures using IMSI (intracytoplasmic morphologically selected sperm injection) with ICSI (intracytoplasmic sperm injection) by means of neonatal outcomes.

Methods: In a retrospective two-center analysis, a total of 848 successful IMSI or ICSI cycles ending with a live birth, induced abortion, or intrauterine fetal death (IUFD) were included.

Results: The IMSI and ICSI groups included 332 and 655 babies or fetuses, respectively. The parents were older in the IMSI group than in the ICSI group (mothers were 35.1 vs 32.9 years, and fathers were 39.1 vs 36.2 years). The multiple pregnancy rate was higher in the IMSI group. The mean pregnancy duration and mean birth weight were almost identical in both groups. There was no significant difference in major congenital malformations between the two groups. However, this rate was decreased in the IMSI group compared to that in the ICSI group (1.8 vs 3.2%), the difference being mainly found in singletons (1.4 vs 3.3%). Boys were more often affected than girls in both groups. The percentages of chromosomal abnormalities did not differ between the IMSI and ICSI groups (0.6 and 0.8%). The reported congenital malformations mainly affected the heart, urogenital, and musculoskeletal systems.

Conclusions: In the present study, the malformation rates observed in the IMSI and ICSI groups were not significantly different, even if slightly lower after IMSI. However, the observed difference followed the same trends observed in previous reports, indicating the possible impact of IMSI on decreasing congenital malformation occurrences. This highlights the necessity to prospectively evaluate the impact of IMSI on neonatal outcome after IVF treatment.

Keywords: Intracytoplasmic morphologically selected sperm injection; Major congenital malformations; Neonatal outcomes; Spermatozoa selection; Vacuole-like structures.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Fig. 1
Fig. 1
Flowchart of the study design
See this image and copyright information in PMC

References

    1. David G, Bisson J, Czyglik F, Jouannet P, Gernigo N. Anomalies morphologiques du spermatozoïde humain. (1) Propositions pour un système de classification. J Gynecol Obstet Biol Reprod. 1975;4:17–36.
    1. Kruger T, Menkveld R, Stander F, Lombard C, Van der Merwe J, van Zyl J, et al. Sperm morphologic features as a prognostic factor in in vitro fertilization. Fertil Steril. 1986;46:1118–1123. doi: 10.1016/S0015-0282(16)49891-2. - DOI - PubMed
    1. Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HWG, Behre HM, Haugen TB, Kruger T, Wang C, Mbizvo MT, Vogelsong KM. World Health Organization reference values for human semen characteristics. Hum Reprod Update. 2010;16:231–245. doi: 10.1093/humupd/dmp048. - DOI - PubMed
    1. Bartoov B, Berkovitz A, Eltes F. Selection of spermatozoa with normal nuclei to improve the pregnancy rate with intracytoplasmic sperm injection. N Engl J Med. 2001;345:1067–1068. doi: 10.1056/NEJM200110043451416. - DOI - PubMed
    1. Tanaka A, Nagayoshi M, Tanaka I, Kusunoki H. Human sperm head vacuoles are physiological structures formed during the sperm development and maturation process. Fertil Steril. 2012;98:315–320. doi: 10.1016/j.fertnstert.2012.04.034. - DOI - PubMed

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