doi: 10.1084/jem.166.5.1573.
Inhibition of suppressor T lymphocytes by murine interferon beta
Affiliations
- PMID: 2960771
- PMCID: PMC2189656
- DOI: 10.1084/jem.166.5.1573
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Inhibition of suppressor T lymphocytes by murine interferon beta
J Exp Med.
.
Abstract
We have presented data showing that IFN-beta at 1,000 U/mouse i.v. inhibits the generation of Ts-mediated tolerance to dinitrofluorobenzene (DNFB) and abrogates the transfer of suppression by Ts. We have also presented data showing that IFN-beta up to 10,000 U/mouse i.v. has no adverse effect on sensitization and elicitation. IFN-beta appears to be a suitable agent for evaluation as an adjunct in the immunotherapy of Ts inducing tumors.
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