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. 2018 Jul/Aug;24(6):839-843.
doi: 10.1089/mdr.2017.0353. Epub 2018 Apr 2.

Surveillance of Drug-Resistant Tuberculosis in Spain (2001-2015)

Juan Bautista Gutiérrez-Aroca  1   2 , Pilar Ruiz  1 , Manuel Vaquero  1 , Manuel Causse  2 , Manuel Casal  1   2
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Free article

Surveillance of Drug-Resistant Tuberculosis in Spain (2001-2015)

Juan Bautista Gutiérrez-Aroca et al. Microb Drug Resist. 2018 Jul/Aug.
Free article

Abstract

Multidrug-resistant tuberculosis (MDR-TB) is a cause of increasing concern. This study investigated first-line anti-TB drug resistance in Mycobacterium tuberculosis strains submitted to the Tuberculosis Reference Center in Córdoba (Spain) between 2001 and 2015. A total of 1,207 cultures were tested against first-line drugs using the BACTEC MGIT 960 system. Resistance to first-line drugs was detected in 207 strains (17.2%), the greatest resistance being found in INH (5.3%) followed by streptomycin (3%), pyrazinamide (2.2%), rifampicin (1%), and ethambutol (0.2%). A total of 1.9% of strains were MDR-TB. Six strains displayed resistance to four drugs, and three strains to five drugs. In view of resistance observed, careful surveillance of drug resistance is recommended.

Keywords: mycobacterium; resistance; tuberculosis.

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