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. 2018 Mar 20;98(11):831-836.
doi: 10.3760/cma.j.issn.0376-2491.2018.11.008.

[Relationships between percentage of skeletal muscle mass and cardiorespiratory fitness in elderly patients with coronary heart disease]

[Article in Chinese]
Y P Wang  1 , S H Yao, D Liu, T Shen, W Zhao, W Gao, S L Xu
Affiliations

[Relationships between percentage of skeletal muscle mass and cardiorespiratory fitness in elderly patients with coronary heart disease]

[Article in Chinese]
Y P Wang et al. Zhonghua Yi Xue Za Zhi. .

Abstract
in English, Chinese

Objective: To determine the relative percentage of skeletal muscle mass (SMM) in elderly patients with coronary heart disease, analyse the relationship between percentage of SMM and cardiorespiratory fitness (CRF), predict exercise capacity and cardiac reserve. Methods: Patients aged 65 years and over after PCI, receiving cardiopulmonary exercise testing (CPET) during February 2014 to December 2016 in Department of Cardiology at Peking University Third Hospital were enrolled.All patients' basic data, percentage of SMM and CPET related parameters, including peak oxygen uptake (VO(2)peak), oxygen pulse (VO(2)/HR), oxygen uptake efficiency slope (OUES) and other cardiorespiratory endurance indicators were collected, to do correlation analysis. Results: There were 402 patients enrolled, with average age (71±5) years, including 283 cases of male (70.40%) and 119 cases of female patients (29.60%). There were 62 patients with acute myocardial infarction (15.42%), 113 patients with old myocardial infarction (28.11%), and 227 patients diagnosed with angina pectoris (56.47%). The percentage of SMM was correlated to CRF.The percentage of SMM[97.00 (92.05, 102.10)%] and VO(2)/HR (r=0.231, P<0.001) and OUES (r=0.264, P<0.001) were positively correlated.Body mass index was negatively correlated with VO(2)peak(r=-0.162, P=0.001). Visceral fat area (VFA) was also negatively correlated with VO(2)peak(r=-0.126, P=0.016). Multiple linear regression analysis showed that Body mass index and VFA were negatively correlated with VO(2)peak (r=-0.204, P=0.014; r=-0.031, P=0.013). The percentage of SMM was positively independently correlated with OUES(r=11.020, P<0.001). Conclusions: Muscle content is positively correlated with exercise capacity of patients.The percentage of skeletal muscle mass determines the core index of cardiorespiratory fitness, such as the slope of oxygen pulse and oxygen uptake efficiency.These indexes can be used as an important criterion for predicting and guiding rehabilitation exercise in patients with coronary heart disease.

目的： 测定老年冠心病患者的骨骼肌质量(SMM)比重，分析患者SMM比重与心肺耐力(CRF)的关系，预测患者的运动能力和心脏储备。 方法： 入选2014年2月至2016年12月期间在北京大学第三医院心内科接受心脏康复评定，且符合入组标准的65岁及以上冠脉介入术后患者。采集所有患者基本资料、SMM比重，CPET相关参数做相关性分析。 结果： 入选患者共402例，年龄(71±5)岁，其中男283例(70.40%)，女119例(29.60%)，急性心肌梗死患者共62例(15.42%)、陈旧性心肌梗死患者共113例(28.11%)、心绞痛患者共227例(56.47%)。SMM比重与CRF相关，SMM比重[97.00(92.05，102.10)%]与氧脉搏(VO(2)/HR)和摄氧效率斜率(OUES)均呈正相关(r＝0.231，P<0.001和r＝0.264，P<0.001)，体质指数(BMI)与峰值摄氧量(VO(2)peak)呈负相关(r＝－0.162，P＝0.001),内脏脂肪面积与VO(2)peak呈负相关(r＝－0.126，P＝0.016)。多元线性回归分析显示：BMI与VO(2)peak(r＝－0.204，P＝0.014)、内脏脂肪面积与VO(2)peak(r＝－0.031，P＝0.013)呈独立负相关；SMM比重与OUES(r＝11.020，P<0.001)呈独立正相关。 结论： 肌肉含量与患者的运动能力呈正相关，骨骼肌质量比重决定了心肺耐力的核心指标，氧脉搏和摄氧效率斜率，可以作为冠心病患者运动能力预测与指导康复运动的重要标准。.

Keywords: Cardiopulmonary exercise testing; Cardiorespiratory fitness; Oxygen uptake efficiency slope; Skeletal muscle mass.

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