Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Apr 2;19(1):77.
doi: 10.1186/s12882-018-0875-8.

Metformin associated lactic acidosis: a case series of 28 patients treated with sustained low-efficiency dialysis (SLED) and long-term follow-up

Andrea Angioi  1 , Gianfranca Cabiddu  1 , Maura Conti  1 , Gianfranco Pili  1 , Alice Atzeni  1 , Valeria Matta  1 , Riccardo Cao  1 , Matteo Floris  1 , Marco Songini  2 , Maria Franca Mulas  2 , Mitchell Rosner  3 , Antonello Pani  4
Affiliations

Metformin associated lactic acidosis: a case series of 28 patients treated with sustained low-efficiency dialysis (SLED) and long-term follow-up

Andrea Angioi et al. BMC Nephrol. .

Abstract

Background: Metformin associated lactic acidosis (MALA) is a well-known serious side effect of biguanides. However, the best treatment strategy remains a matter of debate. In the last 14 years, we observed a significant increase in hospitalizations for MALA to our Center. We report the outcomes of our clinical and therapeutic approach.

Methods: This is a single-center case series. Twenty-eight patients affected with MALA and acute kidney failure admitted between January 2000 and September 2014 were included. We analyzed comorbidities, laboratory tests and clinical parameters at admission, at 36 h and at discharge. All patients were treated with sustained low-efficiency dialysis (SLED) until normalization of serum lactate (≤ 3 mmol/L), bicarbonate (between 20 and 25 mmol/L) and potassium (between 4.0 and 5.1 mmol/L).

Results: The mortality rate was 21.4%, with all of the events occurring within 24 h from admission, and before or during the first hemodialysis treatment. Precipitating causes included; acute dehydration (86.4%), systemic inflammatory response syndrome (SIRS) (57.1%), sepsis (10.7%), nephrolithiasis (14.6%) and exposure to iodinated contrast (7.1%). No further episodes of lactic acidosis were described after discontinuing the drug over a mean follow-up of 27.2 months. Furthermore, while in 2010, we had a peak incidence of MALA of 76.8 cases per 100,000 patients on metformin, this rate fell after an education campaign conducted by specialists on the proper usage of metformin in patients at risk of MALA. Although the fall in incidence after the educational program was not necessarily causal, in 2014 the incidence was 32.9/100,000.

Conclusions: We report an improved mortality rate in patients affected with MALA and acute kidney injury treated with SLED compared with other series published in literature. Rapid introduction of effective hemodialysis is critical in improving outcomes.

Keywords: Acute kidney injury; Hemodialysis; Lactic acidosis; Metformin; SLED.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

The current study has been approved by the ethics committee of Azienda Ospedaliera G. Brotzu; at the admission, we asked for a written consent to every patient (or their relatives when patients were not able to give a consent). This retrospective research involved human subjects and human data. The dataset has been built in an anonymous way by direct care physicians. Only direct care physicians had the access to this database. No other third persons were allowed to consult this database, although totally anonymized. This study has been performed in accordance with the Declaration of Helsinki.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests. Dr. Antonello Pani is a member of the editorial board (Associate Editor) of this Journal.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Kaplan-Meier survival curve of admitted-discharged patients affected with MALA (admission, time 0 – 25 days). Discharged patients are marked as censored. During the follow-up (mean 27.2 months), none of the surviving patients experienced new episodes of lactic acidosis after discontinuing the drug. Two patients died at follow-up for reasons other than lactic acidosis
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Grant RW, Kirkman MS. Trends in the Evidence Level for the American Diabetes Association's “Standards of Medical Care in Diabetes” From 2005 to 2014. Diabetes Care. 2015;38(1):6–8. doi: 10.2337/dc14-2142. - DOI - PubMed
    1. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34) UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998;352(9131):854–865. doi: 10.1016/S0140-6736(98)07037-8. - DOI - PubMed
    1. Associazione Medici Diabetologi. Standard italiani per la cura del diabete mellito 2014 wwwstandarditalianiit 2014.
    1. DeFronzo RA, Goodman AM. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. N Engl J Med. 1995;333(9):541–549. doi: 10.1056/NEJM199508313330902. - DOI - PubMed
    1. National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes statistics. Bethesda (MD): US Department of Health and Human Services. NIH publication 2014(Report no.: 94-3822).