Risk factors for neonatal early-onset group B streptococcus-related diseases after the implementation of a universal screening program in Taiwan

doi:10.1186/s12889-018-5358-0

. 2018 Apr 2;18(1):438.

doi: 10.1186/s12889-018-5358-0.

Risk factors for neonatal early-onset group B streptococcus-related diseases after the implementation of a universal screening program in Taiwan

Li-Chen Hung^{1

2}, Pei-Tseng Kung^{3

4}, Tsan-Hung Chiu⁵, Hsun-Pi Su⁶, Ming Ho⁵, Hui-Fen Kao^{3

7}, Li-Ting Chiu⁸, Kuang-Hua Huang⁸, Wen-Chen Tsai⁹

Affiliations

¹ Department of Public Health, China Medical University, Taichung, Taiwan, Republic of China.
² Department of Healthcare Management, Yuanpei University of Medical Technology, Hsinchu, Taiwan, Republic of China.
³ Department of Healthcare Administration, Asia University, Taichung, Taiwan, Republic of China.
⁴ Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, Republic of China.
⁵ Department of Obstetrics and Gynecology, China Medical University Hospital, China Medical University, Taichung, Taiwan, Republic of China.
⁶ Department of Dental Hygiene, China Medical University, Taichung, Taiwan, Republic of China.
⁷ Department of Obstetrics and Gynecology, Asia University Hospital, Taichung, Taiwan, Republic of China.
⁸ Department of Health Services Administration, China Medical University, 91 Hsueh-Shih Road, Taichung, Taiwan, Republic of China, 40402.
⁹ Department of Health Services Administration, China Medical University, 91 Hsueh-Shih Road, Taichung, Taiwan, Republic of China, 40402. wtsai@mail.cmu.edu.tw.

PMID: 29609583
PMCID: PMC5880064
DOI: 10.1186/s12889-018-5358-0

Risk factors for neonatal early-onset group B streptococcus-related diseases after the implementation of a universal screening program in Taiwan

Li-Chen Hung et al. BMC Public Health. 2018.

. 2018 Apr 2;18(1):438.

doi: 10.1186/s12889-018-5358-0.

Authors

Li-Chen Hung^{1

2}, Pei-Tseng Kung^{3

4}, Tsan-Hung Chiu⁵, Hsun-Pi Su⁶, Ming Ho⁵, Hui-Fen Kao^{3

7}, Li-Ting Chiu⁸, Kuang-Hua Huang⁸, Wen-Chen Tsai⁹

Affiliations

¹ Department of Public Health, China Medical University, Taichung, Taiwan, Republic of China.
² Department of Healthcare Management, Yuanpei University of Medical Technology, Hsinchu, Taiwan, Republic of China.
³ Department of Healthcare Administration, Asia University, Taichung, Taiwan, Republic of China.
⁴ Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, Republic of China.
⁵ Department of Obstetrics and Gynecology, China Medical University Hospital, China Medical University, Taichung, Taiwan, Republic of China.
⁶ Department of Dental Hygiene, China Medical University, Taichung, Taiwan, Republic of China.
⁷ Department of Obstetrics and Gynecology, Asia University Hospital, Taichung, Taiwan, Republic of China.
⁸ Department of Health Services Administration, China Medical University, 91 Hsueh-Shih Road, Taichung, Taiwan, Republic of China, 40402.
⁹ Department of Health Services Administration, China Medical University, 91 Hsueh-Shih Road, Taichung, Taiwan, Republic of China, 40402. wtsai@mail.cmu.edu.tw.

PMID: 29609583
PMCID: PMC5880064
DOI: 10.1186/s12889-018-5358-0

Abstract

Background: We examined the risk for Group B streptococcus (GBS)-related diseases in newborns born to mothers who participated in a universal GBS screening program and to determine whether differences are observed in factors affecting the morbidity for neonatal early-onset GBS-related diseases.

Methods: This is a retrospective study and the study subjects were women who had undergone GBS screening and who gave birth naturally and their newborns between April 15, 2012 and December 31, 2013. Data from the GBS screening system database and the National Health Insurance database were collected to calculate the GBS prevalence in pregnant women and morbidity of newborns with early-onset GBS-related diseases.

Results: The GBS prevalence in pregnant women who gave birth naturally was 19.58%. The rate of early-onset infection caused by GBS in newborns decreased from the original 0.1% to 0.02%, a decrease of as high as 80%. After the implementation of the universal GBS screening program, only three factors, including positive GBS screening result (OR = 2.84), CCI (OR = 2.45), and preterm birth (OR = 4.81) affected the morbidity for neonatal early-onset GBS-related diseases, whereas other factors had no significant impact.

Conclusion: The implementation of the universal GBS screening program decreased the infection rate of neonatal early-onset GBS diseases. The effects of socioeconomic factors and high-risk pregnancy on early-onset GBS infections were weakened.

Keywords: Early-onset GBS-related disease; Group B streptococcus; Newborn; Preterm birth; Universal screening.

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Conflict of interest statement

Ethics approval and consent to participate

Our study was approved by the China Medical University & Hospital Research Ethics Committee (IRB number: CMUH104-REC3–082). As this was a retrospective study using de-identified data, no consent was required.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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References

1. Schrag SJ, Zywicki S, Farley MM, Reingold AL, Harrison LH, Lefkowitz LB, et al. Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis. N Engl J Med. 2000;342:15–20. doi: 10.1056/NEJM200001063420103. - DOI - PubMed
1. Liao CH, Huang LH, Lu CY, Lee CY, Hsueh PR, Tsao PN, et al. Group B streptococcus infection in infancy: 21-year experience. Acta Paediatr. 2001;43:326–329. - PubMed
1. Chung MY, Ko DJ, Chen CC, Huang CB, Chung CH, Chen FS, et al. Neonatal group B streptococcal infection: a 7-year experience. Chang Gung Med J. 2004;27:501–508. - PubMed
1. Phares CR, Lynfield R, Farley MM, Mohle-Boetani J, Harrison LH, Petit S, et al. Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005. JAMA. 2008;299:2056–2065. doi: 10.1001/jama.299.17.2056. - DOI - PubMed
1. Health Promotion Administration, Ministry of Health and Welfare, Executive Yuan. Maternal group B streptococcus screening service subsidy program. 2013. https://www.hpa.gov.tw/Pages/List.aspx?nodeid=196. Accessed 18 Oct 2013.

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[1] Schrag SJ, Zywicki S, Farley MM, Reingold AL, Harrison LH, Lefkowitz LB, et al. Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis. N Engl J Med. 2000;342:15–20. doi: 10.1056/NEJM200001063420103. - DOI - PubMed

[2] Schrag SJ, Zywicki S, Farley MM, Reingold AL, Harrison LH, Lefkowitz LB, et al. Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis. N Engl J Med. 2000;342:15–20. doi: 10.1056/NEJM200001063420103. - DOI - PubMed

[3] Liao CH, Huang LH, Lu CY, Lee CY, Hsueh PR, Tsao PN, et al. Group B streptococcus infection in infancy: 21-year experience. Acta Paediatr. 2001;43:326–329. - PubMed

[4] Liao CH, Huang LH, Lu CY, Lee CY, Hsueh PR, Tsao PN, et al. Group B streptococcus infection in infancy: 21-year experience. Acta Paediatr. 2001;43:326–329. - PubMed

[5] Chung MY, Ko DJ, Chen CC, Huang CB, Chung CH, Chen FS, et al. Neonatal group B streptococcal infection: a 7-year experience. Chang Gung Med J. 2004;27:501–508. - PubMed

[6] Chung MY, Ko DJ, Chen CC, Huang CB, Chung CH, Chen FS, et al. Neonatal group B streptococcal infection: a 7-year experience. Chang Gung Med J. 2004;27:501–508. - PubMed

[7] Phares CR, Lynfield R, Farley MM, Mohle-Boetani J, Harrison LH, Petit S, et al. Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005. JAMA. 2008;299:2056–2065. doi: 10.1001/jama.299.17.2056. - DOI - PubMed

[8] Phares CR, Lynfield R, Farley MM, Mohle-Boetani J, Harrison LH, Petit S, et al. Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005. JAMA. 2008;299:2056–2065. doi: 10.1001/jama.299.17.2056. - DOI - PubMed

[9] Health Promotion Administration, Ministry of Health and Welfare, Executive Yuan. Maternal group B streptococcus screening service subsidy program. 2013. https://www.hpa.gov.tw/Pages/List.aspx?nodeid=196. Accessed 18 Oct 2013.

[10] Health Promotion Administration, Ministry of Health and Welfare, Executive Yuan. Maternal group B streptococcus screening service subsidy program. 2013. https://www.hpa.gov.tw/Pages/List.aspx?nodeid=196. Accessed 18 Oct 2013.

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Risk factors for neonatal early-onset group B streptococcus-related diseases after the implementation of a universal screening program in Taiwan

Affiliations

Risk factors for neonatal early-onset group B streptococcus-related diseases after the implementation of a universal screening program in Taiwan

Authors

Affiliations

Abstract

Conflict of interest statement

Ethics approval and consent to participate

Consent for publication

Competing interests

Publisher’s Note

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

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