New insight into type 1 diabetes development: resolving early diabetogenic CD4⁺ T cell responses that precede seroconversion

Sonja Schallenberg¹, Karsten Kretschmer^{1

2

3}

Affiliations

¹ Molecular and Cellular Immunology/Immune Regulation, DFG-Center for Regenerative Therapies Dresden (CRTD), Center for Molecular and Cellular Bioengeneering (CMCB), Technische Universität Dresden, Dresden, Germany.
² Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Hospital and Medical Faculty Carl Gustav Carus of TU Dresden, Dresden, Germany.
³ German Center for Diabetes Research (DZD e.V.), Ingolstädter Landstraße 1, Neuherberg, Germany.

Editorial

Sonja Schallenberg et al. Ann Transl Med. 2018 Feb.

. 2018 Feb;6(3):58.

doi: 10.21037/atm.2017.12.14.

Sonja Schallenberg¹, Karsten Kretschmer^{1

2

3}

¹ Molecular and Cellular Immunology/Immune Regulation, DFG-Center for Regenerative Therapies Dresden (CRTD), Center for Molecular and Cellular Bioengeneering (CMCB), Technische Universität Dresden, Dresden, Germany.
² Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Hospital and Medical Faculty Carl Gustav Carus of TU Dresden, Dresden, Germany.
³ German Center for Diabetes Research (DZD e.V.), Ingolstädter Landstraße 1, Neuherberg, Germany.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interests to declare.

A divergent population of autoantigen-responsive CD4⁺ T cells in infants prior to β cell autoimmunity.
Heninger AK, Eugster A, Kuehn D, Buettner F, Kuhn M, Lindner A, Dietz S, Jergens S, Wilhelm C, Beyerlein A, Ziegler AG, Bonifacio E. Heninger AK, et al. Sci Transl Med. 2017 Feb 22;9(378):eaaf8848. doi: 10.1126/scitranslmed.aaf8848. Sci Transl Med. 2017. PMID: 28228602

1. Wållberg M, Cooke A. Immune mechanisms in type 1 diabetes. Trends Immunol 2013;34:583-91. 10.1016/j.it.2013.08.005 - DOI - PubMed
1. McKnight JA, Wild SH, Lamb MJ, et al. Glycaemic control of Type 1 diabetes in clinical practice early in the 21st century: an international comparison. Diabet Med 2015;32:1036-50. 10.1111/dme.12676 - DOI - PubMed
1. Bluestone JA, Herold K, Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 2010;464:1293-300. 10.1038/nature08933 - DOI - PMC - PubMed
1. LaGasse JM, Brantley MS, Leech NJ, et al. Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies: an 8-year follow-up of the Washington State Diabetes Prediction Study. Diabetes Care 2002;25:505-11. 10.2337/diacare.25.3.505 - DOI - PubMed
1. Ziegler AG, Rewers M, Simell O, et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 2013;309:2473-9. 10.1001/jama.2013.6285 - DOI - PMC - PubMed