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Review
. 2018 Dec;38(12):1450-1459.
doi: 10.1002/jat.3623. Epub 2018 Apr 3.

Deoxynivalenol as potential modulator of human steroidogenesis

Kinga Anna Urbanek  1 , Dominika Ewa Habrowska-Górczyńska  1 , Karolina Kowalska  1 , Anna Stańczyk  2 , Kamila Domińska  3 , Agnieszka Wanda Piastowska-Ciesielska  1
Affiliations
Review

Deoxynivalenol as potential modulator of human steroidogenesis

Kinga Anna Urbanek et al. J Appl Toxicol. 2018 Dec.

Abstract

Deoxynivalenol (DON) is a type B trichothecene, produced by the Fusarium species. Exposure to DON might cause disruptive effects such as reduced weight gain, neuroendocrine changes and immune modulation in animals (rats, dogs, pigs). There is huge concern that similar effects can be observed in humans. DON is a potential regulator of intracellular steroidogenesis. It is also possible that DON will be involved in the regulation of miRNAs connected with steroidogenesis. This review summarizes the latest knowledge about the influence of DON on steroidogenesis and human hormonal balance.

Keywords: cancerogenesis; deoxynivalenol; miRNA; mycotoxin; steroidogenesis.

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