Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Mar 31;10(4):438.
doi: 10.3390/nu10040438.

Dietary Flavonoids in the Prevention of T2D: An Overview

Hana Alkhalidy  1   2 , Yao Wang  3 , Dongmin Liu  4
Affiliations
Review

Dietary Flavonoids in the Prevention of T2D: An Overview

Hana Alkhalidy et al. Nutrients. .

Abstract

Type 2 diabetes (T2D) is a progressive metabolic disease that is increasing in prevalence globally. It is well established that insulin resistance (IR) and a progressive decline in functional β-cell mass are hallmarks of developing T2D. Obesity is a leading pathogenic factor for developing IR. Constant IR will progress to T2D when β-cells are unable to secret adequate amounts of insulin to compensate for decreased insulin sensitivity. Recently, a considerable amount of research has been devoted to identifying naturally occurring anti-diabetic compounds that are abundant in certain types of foods. Flavonoids are a group of polyphenols that have drawn great interest for their various health benefits. Results from many clinical and animal studies demonstrate that dietary intake of flavonoids might be helpful in preventing T2D, although cellular and molecular mechanisms underlying these effects are still not completely understood. This review discusses our current understanding of the pathophysiology of T2D and highlights the potential anti-diabetic effects of flavonoids and mechanisms of their actions.

Keywords: flavonoids; insulin resistance; type 2 diabetes.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
General structure of flavonoids.
See this image and copyright information in PMC

References

    1. Centers of Disease Control and Prevention . National Diabetes Statistics Report: Estimates of Diabetes and its Burden in the United States, 2014. Centers of Disease Control and Prevention; Atlanta, GA, USA: 2014.
    1. Boyle J.P., Thompson T.J., Gregg E.W., Barker L.E., Williamson D.F. Projection of the year 2050 burden of diabetes in the us adult population: Dynamic modeling of incidence, mortality, and prediabetes prevalence. Popul. Health Metr. 2010;8:29. doi: 10.1186/1478-7954-8-29. - DOI - PMC - PubMed
    1. Zimmet P. The burden of type 2 diabetes: Are we doing enough? Diabetes Metab. 2003;29:6S9–6S18. doi: 10.1016/S1262-3636(03)72783-9. - DOI - PMC - PubMed
    1. Assoc A.D. Economic costs of diabetes in the U.S. in 2012. Diabetes Care. 2013;36:1033–1046. - PMC - PubMed
    1. American Diabetes Association Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010;33:S62–S69. - PMC - PubMed

LinkOut - more resources