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Comment
. 2018 Aug;29(8):527-529.
doi: 10.1016/j.tem.2018.03.015. Epub 2018 Mar 31.

The Endothelial-Metabolic Axis: A Novel Cardiometabolic Disease Target

Jason C Kovacic  1
Affiliations
Comment

The Endothelial-Metabolic Axis: A Novel Cardiometabolic Disease Target

Jason C Kovacic. Trends Endocrinol Metab. 2018 Aug.

Abstract

Endothelial to mesenchymal transition (EndMT) involves cellular phenotypic switching from an endothelial to mesenchymal state. Interest in EndMT has been increasing with the appreciation that it has an important role in several cardiovascular diseases. New evidence indicates that fatty acid oxidation (FAO) and cell metabolism are major factors controlling this process.

Keywords: EndMT; cardiovascular; endothelial; endothelial to mesenchymal transition; fatty acid oxidation; metabolic.

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Figures

Figure
Figure. EndMT and its key signaling pathways
At the top is shown typical endothelial cells with underlying basement membrane. With EndMT, endothelial cells undergo a series of fundamental phenotypic changes and acquire a mesenchymal cell phenotype (bottom). Figure produced using Servier medical art.
See this image and copyright information in PMC

Comment on

  • A Metabolic Basis for Endothelial-to-Mesenchymal Transition.
    Xiong J, Kawagishi H, Yan Y, Liu J, Wells QS, Edmunds LR, Fergusson MM, Yu ZX, Rovira II, Brittain EL, Wolfgang MJ, Jurczak MJ, Fessel JP, Finkel T. Xiong J, et al. Mol Cell. 2018 Feb 15;69(4):689-698.e7. doi: 10.1016/j.molcel.2018.01.010. Epub 2018 Feb 8. Mol Cell. 2018. PMID: 29429925 Free PMC article.

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