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Comment
. 2018 May;8(5):525-526.
doi: 10.1158/2159-8290.CD-NB2018-038. Epub 2018 Apr 3.

Screening Tool for Gynecologic Cancers Assessed

No authors listed
Comment

Screening Tool for Gynecologic Cancers Assessed

No authors listed. Cancer Discov. 2018 May.

Abstract

Researchers have developed a test called PapSEEK that detects endometrial and ovarian cancers by analyzing DNA samples for mutations and aberrations in chromosome number. In a large, retrospective study, the test detected 81% of endometrial cancers and 33% of ovarian cancers with a low false-positive rate.

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  • Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers.
    Wang Y, Li L, Douville C, Cohen JD, Yen TT, Kinde I, Sundfelt K, Kjær SK, Hruban RH, Shih IM, Wang TL, Kurman RJ, Springer S, Ptak J, Popoli M, Schaefer J, Silliman N, Dobbyn L, Tanner EJ, Angarita A, Lycke M, Jochumsen K, Afsari B, Danilova L, Levine DA, Jardon K, Zeng X, Arseneau J, Fu L, Diaz LA Jr, Karchin R, Tomasetti C, Kinzler KW, Vogelstein B, Fader AN, Gilbert L, Papadopoulos N. Wang Y, et al. Sci Transl Med. 2018 Mar 21;10(433):eaap8793. doi: 10.1126/scitranslmed.aap8793. Sci Transl Med. 2018. PMID: 29563323 Free PMC article.

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