Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Feb:144:145-52.

Vascular and neural changes in the rat optic nerve following induction of diabetes with streptozotocin

T M Scott  1 , J Foote, B Peat, G Galway
Affiliations

Vascular and neural changes in the rat optic nerve following induction of diabetes with streptozotocin

T M Scott et al. J Anat. 1986 Feb.

Abstract

This study was undertaken to determine whether or not changes occur in blood vessels, axons or glia of the optic nerve as the result of streptozotocin-induced diabetes. Diabetes was induced in 4 weeks old Sprague-Dawley rats. At 12 and 16 weeks of age, the rats were killed and the optic nerves prepared for examination. The number and density of blood vessels was found to be significantly increased in the diabetic rats. No alteration in the structure of the blood vessels was noted. A decrease in the percentage volume of axons and an increase in the percentage volume of glial elements accompanied the increase in blood vessels in the diabetic rats. No difference was found in the spectrum of fibre diameters.

PubMed Disclaimer

References

    1. J Anat. 1984 Jun;138 ( Pt 4):635-42 - PubMed
    1. Science. 1966 Jan 14;151(3707):209-10 - PubMed
    1. Am J Ophthalmol. 1965 Jul;60:18-20 - PubMed
    1. J Neurochem. 1967 Nov;14(11):1057-66 - PubMed
    1. Diabetes. 1975 Oct;24(10):944-57 - PubMed

LinkOut - more resources