Resistance to Dolutegravir-A Chink in the Armor?
- PMID: 29617815
- PMCID: PMC6057516
- DOI: 10.1093/infdis/jiy186
Resistance to Dolutegravir-A Chink in the Armor?
Comment in
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Dolutegravir Resistance and Failure in a Kenyan Patient.J Infect Dis. 2019 Jan 1;219(1):165-167. doi: 10.1093/infdis/jiy436. J Infect Dis. 2019. PMID: 30165703 No abstract available.
Comment on
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HIV-1 Resistance Dynamics in Patients With Virologic Failure to Dolutegravir Maintenance Monotherapy.J Infect Dis. 2018 Jul 24;218(5):688-697. doi: 10.1093/infdis/jiy176. J Infect Dis. 2018. PMID: 29617822
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The S230R Integrase Substitution Associated With Virus Load Rebound During Dolutegravir Monotherapy Confers Low-Level Resistance to Integrase Strand-Transfer Inhibitors.J Infect Dis. 2018 Jul 24;218(5):698-706. doi: 10.1093/infdis/jiy175. J Infect Dis. 2018. PMID: 29617824 Free PMC article.
References
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- Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in adults and adolescents living with HIV. Department of Health and Human Services; http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf. Accessed 25 March 2018.
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- Lennox JL, DeJesus E, Lazzarin A, et al. ; STARTMRK Investigators Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial. Lancet 2009; 374:796–806. - PubMed
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- Sax PE, DeJesus E, Mills A, et al. ; GS-US-236-0102 Study Team Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks. Lancet 2012; 379:2439–48. - PubMed
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- Lennox JL, Landovitz RJ, Ribaudo HJ, et al. ; ACTG A5257 Team Efficacy and tolerability of 3 nonnucleoside reverse transcriptase inhibitor-sparing antiretroviral regimens for treatment-naive volunteers infected with HIV-1: a randomized, controlled equivalence trial. Ann Intern Med 2014; 161:461–71. - PMC - PubMed
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